Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT

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Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT

Material type: 博士論文

Author: 横田, 和明

Publisher: Springer Japan

Publication date: 2020-09-02

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Introduction: Second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT) has provide higher quality of bone images with a...

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Material Type: 博士論文
Title: Deterioration of bone microstructure by aging and menopause in Japanese healthy women: analysis by HR-pQCT
Author/Editor: 横田, 和明
Author Heading: 横田, 和明
Publication, Distribution, etc.: Springer Japan
Publication Date: 2020-09-02
Publication Date (W3CDTF): 2020-09-02
Alternative Title: 日本人女性における骨微細構造の加齢や閉経による変化：高解像度末梢骨用定量的CTを用いた解析
Periodical title: Journal of Bone and Mineral Metabolism
ISSN (Periodical Title): ISSN : 0914-8779
ISSN : 1435-5604
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2020-09-02
Dissertation Number: 甲医歯薬第1272号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: High resolution peripheral quantitative CT (HR-pQCT)
Bone microstructure
Estimated bone strength
Non-metric trabecular parameter
Japanese women
Target Audience: 一般
Note (General): Introduction: Second-generation high-resolution peripheral quantitative computed tomography (HR-pQCT) has provide higher quality of bone images with a voxel size of 61 μm, enabling direct measurements of trabecular thickness. In addition to the standard parameters, the non-metric trabecular parameters such as trabecular morphology (plate to rod-like structures), connectivity, and anisotropy can also be analyzed. The purpose of this study is to investigate deterioration of bone microstructure in healthy Japanese women by measuring standard and non-metric parameters using HR-pQCT. Materials and methods: Study participants were 61 healthy Japanese women (31?70 years). The distal radius and tibia were scanned using second-generation HR-pQCT, and microstructures of trabecular and cortical bone were measured. Non-metric trabecular parameters included structure model index (SMI), trabecular bone pattern factor (TBPf), connectivity density (Conn.D), number of nodes (N.Nd/TV), degree of anisotropy (DA), and star volume of marrow space (V*ms). Estimated bone strength was evaluated by micro finite element analysis. Associations between bone microstructure, estimated bone strength, age, and menopause were analyzed. Results: Trabecular number declined with age, and trabecular separation increased. SMI and TBPf increased, Conn.D and N.Nd/TV declined, and V*ms increased. Cortical BMD and thickness declined with age, and porosity increased. Stiffness and failure load decreased with age. Cortical thickness and estimated bone strength were affected by menopause. Cortical thickness was most associated with estimated bone strength. Conclusions: Trabecular and cortical bone microstructure were deteriorated markedly with age. Cortical thickness decreased after menopause and was most related to bone strength. Non-metric parameters give additional information about osteoporotic changes of trabecular bone.
長崎大学学位論文学位記番号:博(医歯薬)甲第1272号学位授与年月日:令和2年9月2日
Author: Kazuaki Yokota, Ko Chiba, Narihiro Okazaki, Choko Kondo, Mitsuru Doi, Shuta Yamada, Makoto Era, Yuichiro Nishino, Akihiko Yonekura, Masato Tomita & Makoto Osaki
Citation: Journal of Bone and Mineral Metabolism, Article in Press
identifier:Nagasaki University (長崎大学), 博士(医学) (2020-09-02)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=90&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=90&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Rights (production): c The Japanese Society Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2020This is a post-peer-review, pre-copyedit version of an article published in Journal of Bone and Mineral Metabolism. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00774-020-01115-z.
Related Material: http://hdl.handle.net/10069/40342
Related Material (DOI): 10.1007/s00774-020-01115-z
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ