Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy

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Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy

Material type: 博士論文

Author: 本田, 涼子

Publisher: Elsevier Inc.

Publication date: 2022-03-18

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Aim: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood.Methods: We retrospectively identified 106 pat...

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Material Type: 博士論文
Title: Developmental outcome after corpus callosotomy for infants and young children with drug-resistant epilepsy
Author/Editor: 本田, 涼子
Author Heading: 本田, 涼子
Publication, Distribution, etc.: Elsevier Inc.
Publication Date: 2022-03-18
Publication Date (W3CDTF): 2022-03-18
Alternative Title: 乳幼児の薬剤抵抗性てんかんに対する脳梁離断術後の発達予後
Periodical title: Epilepsy & Behavior
No. or year of volume/issue: 117
Volume: 117
Pages: 107799-
ISSN (Periodical Title): ISSN : 1525-5050
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2022-03-18
Dissertation Number: 甲医歯薬第1444号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: Corpus callosotomy
Developmental outcome
Seizure outcome
Infants and young children
Drug-resistant epilepsy
Target Audience: 一般
Note (General): Aim: To examine the developmental and seizure outcomes after corpus callosotomy (CC) in early childhood.Methods: We retrospectively identified 106 patients who underwent CC for drug-resistant epilepsy before the age of 6 years, at the Nagasaki Medical Center, between July 2002 and July 2016. Patients’ developmental outcomes were evaluated one year after CC using the Kinder Infant Development Scale.Results: The mean preoperative developmental quotient (DQ) was 25.0 (standard deviation [SD], 20.8), and the mean difference between preoperative DQ and one-year postoperative DQ was −1.6 points (SD, 11.6). However, 42.5% of patients had a mean DQ increase of 6.5 points (SD, 6.4), one year after CC from that before surgery. Factors related to the improvement in postoperative DQ were ‘low preoperative DQ’, ‘developmental gain 1 month postoperatively’, and ‘postoperative seizure-free state’. Approximately 21.7% of patients were seizure-free 1 year after CC.Interpretation: Performing CC, in infancy and early childhood for patients with drug-resistant epilepsy and severe developmental impairment, was associated with improved development in 42.5% of patients. Remission of seizures, even if only for a short period, contributed to developmental improvement. From a developmental perspective, CC for drug-resistant epilepsy in early childhood is an effective treatment.
長崎大学学位論文学位記番号:博(医歯薬)甲第1444号学位授与年月日:令和4年3月18日
Author: Ryoko Honda, Hiroshi Baba, Kohei Adachi, Rika Koshimoto, Tomonori Ono, Keisuke Toda, Shigeki Tanaka, Shiro Baba, Kazumi Yamasaki, Hiroshi Yatsuhashi
Citation: Epilepsy & Behavior, 117, art. no. 107799; 2021
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27427&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27427&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Related Material: http://hdl.handle.net/10069/00041447
Related Material (DOI): 10.1016/j.yebeh.2021.107799
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ