Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice

• Material Type: 博士論文
• Title: Mitochonic acid-5 ameliorates chlorhexidine gluconate-induced peritoneal fibrosis in mice
• Author/Editor: 井上, 大
• Author Heading: 井上, 大
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2022-03-18
• Publication Date (W3CDTF): 2022-03-18
• Alternative Title: Mitochonic acid-5はクロルヘキシジングルコン酸塩誘発性マウス腹膜線維化を軽減する
• Periodical title: Medical Molecular Morphology
• No. or year of volume/issue: 55 1
• Volume: 55
• Issue: 1
• Pages: 27-40
• ISSN (Periodical Title): ISSN : 1860-1480; ISSN : 1860-1499
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2022-03-18
• Dissertation Number: 甲医歯薬第1434号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Subject Heading: Peritoneal dialysis; Peritoneal fibrosis; Mitochonic acid-5; Chlorhexidine gluconate
• Target Audience: 一般
• Note (General): Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis, attributable to inflammation and mitochondrial dysfunction. Mitochonic acid-5 (MA-5), an indole-3-acetic acid derivative, improves mitochondrial dysfunction and has therapeutic potential against various diseases including kidney diseases. However, whether MA-5 is effective against peritoneal fibrosis remains unclear. Therefore, we investigated the effect of MA-5 using a peritoneal fibrosis mouse model. Peritoneal fibrosis was induced in C57BL/6 mice via intraperitoneal injection of chlorhexidine gluconate (CG) every other day for 3 weeks. MA-5 was administered daily by oral gavage. The mice were divided into control, MA-5, CG, and CG + MA-5 groups. Following treatment, immunohistochemical analyses were performed. Fibrotic thickening of the parietal peritoneum induced by CG was substantially attenuated by MA-5. The number of α-smooth muscle actin-positive myofibroblasts, transforming growth factor β-positive cells, F4/80-positive macrophages, monocyte chemotactic protein 1-positive cells, and 4-hydroxy-2-nonenal-positive cells was considerably decreased. In addition, reduced ATP5a1-positive and uncoupling protein 2-positive cells in the CG group were notably increased by MA-5. MA-5 may ameliorate peritoneal fibrosis by suppressing macrophage infiltration and oxidative stress, thus restoring mitochondrial function. Overall, MA-5 has therapeutic potential against peritoneal fibrosis.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1434号 学位授与年月日:令和4年3月18日; Author: Hiro Inoue, Kenta Torigoe, Miki Torigoe, Kumiko Muta, Yoko Obata, Takehiro Suzuki, Chitose Suzuki, Takaaki Abe, Takehiko Koji, Hiroshi Mukae & Tomoya Nishino; Citation: Medical Molecular Morphology, 55(1), pp. 27–40; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-03-18)
• Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27438&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27438&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): © The Japanese Society for Clinical Molecular Morphology 2021. This version of the article has been accepted for publication, after peer review and is subject to Springer Nature's AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00795-021-00305-6
• Related Material: http://hdl.handle.net/10069/00041437
• Related Material (DOI): 10.1007/s00795-021-00305-6
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ