Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells

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Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells

Material type: 博士論文

Author: 大橋, 和明

Publisher: International Institute of Anticancer Research

Publication date: 2022-06-01

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Background/Aim: The aim of this study was to clarify the biological differences between ovarian cancerassociated fibroblasts (OCa-CAFs) and normal ova...

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Material Type: 博士論文
Title: Biological Differences Between Ovarian Cancer-associated Fibroblasts and Contralateral Normal Ovary-derived Mesenchymal Stem Cells
Author/Editor: 大橋, 和明
Author Heading: 大橋, 和明
Publication, Distribution, etc.: International Institute of Anticancer Research
Publication Date: 2022-06-01
Publication Date (W3CDTF): 2022-06-01
Alternative Title: 卵巣癌関連線維芽細胞と対側の正常卵巣由来間葉系幹細胞における生物学的特性の相違に関する検討
Periodical title: ANTICANCER RESEARCH
No. or year of volume/issue: 42 4
Volume: 42
Issue: 4
Pages: 1729-1737
ISSN (Periodical Title): ISSN : 0250-7005
ISSN : 1791-7530
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2022-06-01
Dissertation Number: 甲医歯薬第1454号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: Cancer-associated fibroblasts
ovarian cancer
stromal cells
mesenchymal stem cells
normal ovary
Target Audience: 一般
Note (General): Background/Aim: The aim of this study was to clarify the biological differences between ovarian cancerassociated fibroblasts (OCa-CAFs) and normal ovary-derived mesenchymal stem cells (NO-MSCs). Materials and Methods: Surgically resected ovarian cancer and contralateral normal ovarian tissue samples were cut into small pieces for culture as “explants”. The number of outgrown cells, their proliferative kinetics, and expression levels of cell surface markers of CAFs, as well as three miRNAs in OCa-CAFs and NO-MSCs were compared directly. Differentially expressed genes between both groups were also investigated. Results: Comparable numbers of outgrown cells were harvested from both groups. Significantly higher expression of α-smooth muscle actin and miR-142 was found in OCa-CAFs, which decreased significantly during ex vivo cell expansion. A total of 21 differentially expressed genes were identified between both groups. Conclusion: OCa-CAFs showed different biological properties in direct comparison with NO-MSCs, which might play major roles in the pathogenesis of ovarian cancer.
長崎大学学位論文学位記番号:博(医歯薬)甲第1454号学位授与年月日:令和4年6月1日
Author: Kazuaki Ohashi, Tao-Sheng Li, Shoko Miura, Yuri Hasegawa and Kiyonori Miura
Citation: ANTICANCER RESEARCH, 42(4), pp.1729-1737; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-06-01)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27482&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27482&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Rights (production): © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY-NC-ND) 4.0 international license (https://creativecommons.org/licenses/by-nc-nd/4.0).
Related Material: http://hdl.handle.net/10069/00041584
Related Material (DOI): 10.21873/anticanres.15649
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ