Resin-based sealant containing sol-gel derived bioactive glass: ion release and biological response

• Material Type: 博士論文
• Title: Resin-based sealant containing sol-gel derived bioactive glass: ion release and biological response
• Author/Editor: Jafarnia, Shiva
• Author Heading: Jafarnia, Shiva
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2022-03-18
• Publication Date (W3CDTF): 2022-03-18
• Alternative Title: ゾル-ゲル法で作成したバイオ活性ガラス含有レジンシーラントのイオン放出能および生体応答
• Periodical title: Journal of Sol-Gel Science and Technology
• ISSN (Periodical Title): ISSN : 0928-0707; ISSN : 1573-4846
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2022-03-18
• Dissertation Number: 甲医歯薬第1389号
• Degree Type: 博士(歯学)
• Text Language Code: eng
• Subject Heading: Bioactive glass; Biocompatibility; Caries inhibition; Ion release; Resin-based sealant
• Target Audience: 一般
• Note (General): The aim of this study was to examine the effect of bioactive glass (BAG) loading on the ion release, pH changes, and cell response of the experimental pit and fissure sealant containing sol–gel derived 58S BAG. The BAG and silica filler in different proportion were incorporated into a resin matrix with the final filler loading of 50% in all groups. The specimens were immersed in deionized water (pH 5.8) or lactic acid solution (pH 4.0) at different time points (6 h, 1, 7, 14, 30, and 45 days) for ion release and pH changes assessment. Biological properties were evaluated using MTS assay, alkaline phosphatase (ALP) assays, and alizarin red staining. In the deionized water, the BAG50% group pH reaches to 9.3 and in lactic acid solution to 4.31 after 45 days. The BAG filler percentage did not have a significant effect on ion release in the deionized water. However, ion release increased with the pH reduction, particularly in the BAG50% group. The BAG50% group showed less cytotoxicity and higher ALP activity and calcified nodule formation. The experimental pit and fissure sealant with 50% BAG filler loading exhibited an appropriate increase in pH elevation, ion release, and cell proliferation and differentiation. Therefore, it can be concluded that this bioactive sealant has the potential to hinder secondary caries and can be used as a caries-inhibiting material.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1389号 学位授与年月日:令和4年3月18日; Author: Shiva Jafarnia, Alireza Valanezhad, Shigeaki Abe, Sima Shahabi, Ikuya Watanabe; Citation: Journal of Sol-Gel Science and Technology (2021). https://doi.org/10.1007/s10971-021-05551-9; identifier:Nagasaki University (長崎大学), 博士(歯学) (2022-03-18)
• Source: fulltext; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27577&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2021. This is a post-peer-review, pre-copyedit version of an article published in Journal of Sol-Gel Science and Technology. The final authenticated version is available online at: https://doi.org/10.1007/s10971-021-05551-9
• Related Material: http://hdl.handle.net/10069/41150
• Related Material (DOI): 10.1007/s10971-021-05551-9
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ