Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus

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Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus

Material type: 博士論文

Author: Hoang, Thi Thu Trang

Publisher: Elsevier Inc.

Publication date: 2022-09-16

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: Neuropsychiatric systemic lupus erythematosus (NPSLE) varies in presentation and is one of the leading causes of morbidity and mortality among patient...

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Material Type: 博士論文
Title: Measurement of anti-suprabasin antibodies, multiple cytokines and chemokines as potential predictive biomarkers for neuropsychiatric systemic lupus erythematosus
Author/Editor: Hoang, Thi Thu Trang
Author Heading: Hoang, Thi Thu Trang
Publication, Distribution, etc.: Elsevier Inc.
Publication Date: 2022-09-16
Publication Date (W3CDTF): 2022-09-16
Alternative Title: 抗suprabasin抗体、サイトカインおよびケモカインによる神経精神ループスの診断予測バイオマーカーの可能性
Periodical title: Clinical Immunology
No. or year of volume/issue: 237
Volume: 237
Pages: 108980-
ISSN (Periodical Title): ISSN : 1521-6616
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2022-09-16
Dissertation Number: 甲共医歯薬第23号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: Suprabasin
Cytokines
Chemokines
NPSLE
Bayesian posterior predictive values
SOIL
Target Audience: 一般
Note (General): Neuropsychiatric systemic lupus erythematosus (NPSLE) varies in presentation and is one of the leading causes of morbidity and mortality among patients with SLE. This study determined the most critical serum biomarkers for the development of NPSLE as they may have clinical utility prior to the onset of neuropsychiatric symptoms. We retrospectively analyzed 35 NPSLE patients, 34 SLE patients, 20 viral meningitis (VM) patients, and 16 relapsing-remitting multiple sclerosis (MS) patients. We measured anti-suprabasin antibodies concentrations in serum by using Luciferase immunoprecipitation system (LIPS) assay. The serum concentrations of cytokines/chemokines were measured by using multiplex bead-based assay. We found serum FGF-2 level was significantly higher in the NPSLE group compared to the SLE group and the healthy control group. The anti-suprabasin antibody relative concentration (SRC) has high positive predictive values for the development of NPSLE. The most essential biomarkers are VEGF, anti-suprabasin antibodies, sCD40L, IL-10, GRO, MDC, IL-8, IL-9, TNF-α, MIP-1α.
長崎大学学位論文学位記番号:共博(医歯薬)甲第23号学位授与年月日:令和4年9月16日
Author: Trang T.T. Hoang, Kunihiro Ichinose, Shimpei Morimoto, Kaori Furukawa, Ly H.T. Le, Atsushi Kawakami
Citation: Clinical Immunology, 237, art.no.108980; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2022-09-16)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27618&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27618&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Related Material: http://hdl.handle.net/10069/41579
Related Material (DOI): 10.1016/j.clim.2022.108980
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ