Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen

• Material Type: 博士論文
• Title: Recurrence of neovascular age-related macular degeneration after cessation of treat and extend regimen
• Author/Editor: 平田, 佑妃
• Author Heading: 平田, 佑妃
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2022-12-07
• Publication Date (W3CDTF): 2022-12-07
• Alternative Title: 新生血管加齢黄斑変性に対するtreat&extendレジメン中止後の再発
• Periodical title: Scientific Reports
• No. or year of volume/issue: 12
• Volume: 12
• Pages: 14768-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2022-12-07
• Dissertation Number: 甲医歯薬第1472号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Target Audience: 一般
• Note (General): The appropriate timing of treatment cessation after treat and extend (TAE) regimen for age-related macular degeneration has not been established. This study aimed to investigate the incidence and risk factors of recurrence after cessation of the TAE regimen. We included patients who received and discontinued the TAE regimen, after extension of the treatment interval to ≥ 12 weeks. Forty-nine patients were included in the study. The estimated recurrence rates were 33% at 1 year and 48% at 2 years after treatment cessation, respectively. Good visual acuity at cessation and a large number of injections in the 6 months before cessation were significant risk factors. Higher chances of recurrence were associated with < 0.1 logarithm of the minimum angle of resolution (logMAR) at cessation (P < 0.002). Meanwhile, five patients with visual acuity ≥ 1.0 logMAR at cessation did not show recurrence. Among the 25 recurrences, two lines of vision loss were noted in only two cases after resumed treatment. This study confirmed the importance of the number of injections in reducing recurrence and the association between visual acuity and recurrence. Recurrence is generally well-controlled with resumed treatment.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1472号 学位授与年月日:令和4年12月7日; Author: Yuki Hirata, Akio Oishi, Yuki Maekawa, Eiko Tsuiki, Akira Machida, Junko Kurihara & Takashi Kitaoka; Citation: Scientific Reports, 12, art. no. 14768; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-12-07)
• Source: fulltext; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=27894&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• Related Material: http://hdl.handle.net/10069/00041979
• Related Material (DOI): 10.1038/s41598-022-19062-2
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ