High serum concentrations of growth differentiation factor-15 and their association with Crohn's disease and a low skeletal muscle index

• Material Type: 博士論文
• Title: High serum concentrations of growth differentiation factor-15 and their association with Crohn's disease and a low skeletal muscle index
• Author/Editor: 山本, 浩之
• Author Heading: 山本, 浩之
• Publication, Distribution, etc.: Springer Nature
• Publication Date: 2022-12-07
• Publication Date (W3CDTF): 2022-12-07
• Alternative Title: クローン病患者の低骨格筋量におけるGDF-15の有用性について
• Periodical title: Scientific Reports
• No. or year of volume/issue: 12
• Volume: 12
• Pages: 6591-
• ISSN (Periodical Title): ISSN : 2045-2322
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2022-12-07
• Dissertation Number: 甲医歯薬第1476号
• Degree Type: 博士(医学)
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Sarcopenia comprises a low skeletal muscle index (SMI) and low muscle strength (MS) or low physical function. Many sarcopenia biomarkers have been reported. With Crohn’s disease (CD), a low SMI is predictive of intestinal complications. Therefore, many CD studies have reported that sarcopenia is defined by SMI alone. This study investigated the sarcopenia frequency by assessing the SMI and MS of Japanese patients with CD and biomarkers predicting a low SMI. We evaluated the SMI using a bioelectrical impedance analysis, handgrip strength, and C-reactive protein, albumin, interleukin-6, tumor necrosis factor-α, growth differentiation factor (GDF)-8, and GDF-15 levels as biomarker candidates for 78 CD patients at our hospital. Sarcopenia and a low SMI were observed in 7.7% and 42.3% of the patients, respectively. There was a significant difference in the GDF-15 levels of the low SMI group and normal group according to the multivariate analysis (P = 0.028; odds ratio [OR], 1.001; 95% confidence interval [CI] 1.000–1.002). When evaluated by sex, males exhibited a negative correlation between the GDF-15 level and SMI (Pearson’s r = − 0.414; P = 0.0031), and the multivariate analysis indicated a significant difference in the GDF-15 levels (P = 0.011; OR, 1.001; 95% CI 1.000–1.002). GDF-15 levels may indicate a low SMI with CD.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1476号 学位授与年月日:令和4年12月7日; Author: Hiroyuki Yamamoto, Fuminao Takeshima, Masafumi Haraguchi, Yuko Akazawa, Kayoko Matsushima, Moto Kitayama, Kumi Ogihara, Maiko Tabuchi, Keiichi Hashiguchi, Naoyuki Yamaguchi, Hisamitsu Miyaaki, Hisayoshi Kondo & Kazuhiko Nakao; Citation: Scientific Reports, 12, art. no. 6591; 2022; identifier:Nagasaki University (長崎大学), 博士(医学) (2022-12-07)
• Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28174&item_no=1&attribute_id=70&file_no=1 （fulltext）; https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28174&item_no=1&attribute_id=70&file_no=1
• Access Restrictions: インターネット公開
• Rights (production): © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• Related Material: http://hdl.handle.net/10069/00041983
• Related Material (DOI): 10.1038/s41598-022-10587-0
• Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）; https://irdb.nii.ac.jp
• Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ