Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

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Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

Material type: 博士論文

Author: Abdelghany, Lina Abdelhamid Abdelhamid

Publisher: Elsevier Inc.

Publication date: 2023-03-20

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenge...

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Material Type: 博士論文
Title: Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells
Author/Editor: Abdelghany, Lina Abdelhamid Abdelhamid
Author Heading: Abdelghany, Lina Abdelhamid Abdelhamid
Publication, Distribution, etc.: Elsevier Inc.
Publication Date: 2023-03-20
Publication Date (W3CDTF): 2023-03-20
Alternative Title: ニカラベンは、癌細胞におけるBcl-2とポリ（ADP-リボース）グリコヒドロラーゼの発現レベルに応じて、異なる機序でプログラム細胞死を誘導する
Periodical title: Translational Oncology
No. or year of volume/issue: 26
Volume: 26
Pages: 101548-
ISSN (Periodical Title): ISSN : 1936-5233
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2023-03-20
Dissertation Number: 甲医歯薬第1528号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: Nicaraven
PARG
Bcl-2
Parthanatos
Apoptosis
Cancer cells
Target Audience: 一般
Note (General): The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear. In this study, we investigated the potential role and molecular mechanism of nicaraven on cancer cells. Using U937 lymphoma cells and HCT-8 colorectal cancer cells, we found that nicaraven moderately reduced the cell viability of both cells in a dose-dependent manner. Interestingly, nicaraven significantly induced apoptosis of U937 cells that are dominantly expressing Bcl-2 but induced PAR-dependent cell death (parthanatos) of HCT-8 cells that are highly expressing poly (ADP-ribose) glycohydrolase (PARG). Based on our data, nicaraven seems to induce programmed cell death through distinct mechanisms, according to the expression levels of Bcl-2 and PARG in cancer cells.
長崎大学学位論文学位記番号:博(医歯薬)甲第1528号学位授与年月日:令和5年3月20日
Author: Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li
Citation: Translational Oncology, 26, art. no. 101548; 2022
identifier:Nagasaki University (長崎大学), 博士(医学) (2023-03-20)
Source: https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28237&item_no=1&attribute_id=70&file_no=1 （fulltext）
https://nagasaki-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=28237&item_no=1&attribute_id=70&file_no=1
Access Restrictions: インターネット公開
Related Material: http://hdl.handle.net/10069/00042269
Related Material (DOI): 10.1016/j.tranon.2022.101548
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ