Improvement in aged liver regeneration using cell transplantation with chemically induced liver progenitors

Digital data available（長崎大学学術研究成果リポジトリ）

学術機関リポジトリデータベース（IRDB）（機関リポジトリ）

Improvement in aged liver regeneration using cell transplantation with chemically induced liver progenitors

Material type: 博士論文

Author: 松隈, 国仁

Publisher: Japanese Society of Hepato-Biliary-Pancreatic Surgery

Publication date: 2024-06-05

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

View All

Notes on use

Note (General)：: Background: A decrease in the regenerative capacity of age-damaged liver tissue has been reported. Liver progenitor cells may play an important role i...

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Nagasaki University's Academic Output SITE: NAOSITE
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Nagasaki University's Academic Output SITE: NAOSITE

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
Title: Improvement in aged liver regeneration using cell transplantation with chemically induced liver progenitors
Author/Editor: 松隈, 国仁
Author Heading: 松隈, 国仁
Publication, Distribution, etc.: Japanese Society of Hepato-Biliary-Pancreatic Surgery
Publication Date: 2024-06-05
Publication Date (W3CDTF): 2024-06-05
Alternative Title: 化学的に誘導された肝前駆細胞を用いた高齢肝再生能改善に関する研究
Periodical title: Journal of Hepato-Biliary-Pancreatic Sciences
No. or year of volume/issue: 31 6
Volume: 31
Issue: 6
Pages: 376-384
ISSN (Periodical Title): ISSN : 1868-6974
EISSN : 1868-6982
Degree grantor/type: Nagasaki University (長崎大学)
Date Granted: 2024-06-05
Dissertation Number: 甲医歯薬第1618号
Degree Type: 博士(医学)
Text Language Code: eng
Subject Heading: aging
chemically induced
liver regeneration
proge
Target Audience: 一般
Note (General): Background: A decrease in the regenerative capacity of age-damaged liver tissue has been reported. Liver progenitor cells may play an important role in the regeneration of injured livers. In the present study we aimed to investigate improvements in the regenerative capacity of agedamaged livers using chemically induced liver progenitors (CLiPs) derived from mature hepatocytes. Methods: Old (>90 weeks) and young (<20 weeks) mice underwent 70% hepatectomy, with or without trans-splenic CLiP administration. The residual liver/bodyweight (LW/BW) ratio was measured on postoperative days 1 and 7, and changes in liver regeneration and histology were evaluated. Results: At 7 days post-hepatectomy, LW/BW ratios were significantly better in CLiP-treated old mice than in untreated old mice (p = .02). By contrast, no effect of CLiP transplantation was observed in young mice (p = .62). Immunofluorescence staining of liver tissue after CLiP administration showed an increase in Ki67-positive cells (p < .01). Flow cytometry analysis of green fluorescent protein-labeled CLiPs indicated that transplanted CLiPs differentiated into mature hepatocytes and were present in the recipient liver. Conclusions: CLiP transplantation appears to ameliorate the age-related decline in liver regeneration in mice.
長崎大学学位論文学位記番号:博(医歯薬)甲第1618号学位授与年月日:令和6年6月5日
Kunihito Matsuguma, Takanobu Hara, Daisuke Miyamoto, Akihiko Soyama, Hajime Matsushima, Masayuki Fukumoto, Hajime Imamura, Mampei Yamashita, Tomohiko Adachi, Susumu Eguchi
Journal of Hepato-Biliary-Pancreatic Sciences, 31(6), pp.376-384; 2024
Nagasaki University (長崎大学), 博士(医学) (2024-06-05)
Access Restrictions: インターネット公開
Related Material (URI): HDL
http://hdl.handle.net/10069/0002001040
Related Material (DOI): 10.1002/jhbp.1425
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ