Clinical Factors Associated with SFTS Diagnosis and Severity in Cats

Material type: 博士論文

Author: 許, 強

Publisher: MDPI

Publication date: 2024-09-20

Material Format: Digital

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Name of awarding university/degree: Nagasaki University (長崎大学),博士(医学)

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Note (General)：: 出版タイプ： VoRSevere fever with thrombocytopenia syndrome (SFTS) is a potentially fatal tick-borne zoonosis caused by SFTS virus (SFTSV). In addition to t...

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Material Type: 博士論文
Title: Clinical Factors Associated with SFTS Diagnosis and Severity in Cats
Author/Editor: 許, 強
Publication, Distribution, etc.: MDPI
Publication Date: 2024-09-20
Publication Date (W3CDTF): 2024
Alternative Title: 猫のSFTS診断と重症度に関連する臨床的要因
Periodical title: Viruses
No. or year of volume/issue: 16 6
Volume: 16
Issue: 6
Pages: art. no. 874-
ISSN (Periodical Title): EISSN : 1999-4915
Degree grantor/type: Nagasaki University (長崎大学)
Dissertation Number: 甲医歯薬第1646号
Degree Type: 博士(医学)
Subject Heading: severe fever thrombocytopenia syndrome
cat
biomarkers
prognosis factors
veterinarian
Target Audience: 一般
Note (General): 出版タイプ： VoR
Severe fever with thrombocytopenia syndrome (SFTS) is a potentially fatal tick-borne zoonosis caused by SFTS virus (SFTSV). In addition to tick bites, animal-to-human transmission of SFTSV has been reported, but little is known about feline SFTSV infection. In this study, we analyzed data on 187 cats with suspected SFTS to identify biomarkers for SFTS diagnosis and clinical outcome. Body weight, red and white blood cell and platelet counts, and serum aspartate aminotransferase and total bilirubin levels were useful for SFTS diagnosis, whereas alanine aminotransferase, aspartate aminotransferase and serum SFTSV RNA levels were associated with clinical outcome. We developed a scoring model to predict SFTSV infection. In addition, we performed a phylogenetic analysis to reveal the relationship between disease severity and viral strain. This study provides comprehensive information on feline SFTS and could contribute to the protection of cat owners, community members, and veterinarians from the risk of cat-transmitted SFTSV infection.
長崎大学学位論文学位記番号:博(医歯薬)甲第1646号学位授与年月日:令和6年9月20日
Author: Hiromu Osako, Qiang Xu, Takeshi Nabeshima, Jean Claude Balingit, Khine Mya Nwe, Fuxun Yu, Shingo Inoue, Daisuke Hayasaka, Mya Myat Ngwe Tun, Kouichi Morita and Yuki Takamatsu
Citation: Viruses, 16(6), art. no. 874; 2024
Nagasaki University (長崎大学), 博士(医学) (2024-09-20)
Format (IMT): application/pdf
Source: fulltext
https://nagasaki-u.repo.nii.ac.jp/record/2001554/files/ISYK1646_Qiang.pdf
Access Restrictions: インターネット公開
Related Material (URI): HDL
http://hdl.handle.net/10069/0002001525
Related Material (DOI): 10.3390/v16060874
https://doi.org/10.3390/v16060874
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 長崎大学 : 長崎大学学術研究成果リポジトリ