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エクソソームのがん間質傷害作用を利用した腫瘍浸潤がん細胞傷害性T細胞の最適化

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エクソソームのがん間質傷害作用を利用した腫瘍浸潤がん細胞傷害性T細胞の最適化

Material type
文書・図像類
Author
瀬尾, 尚宏
Publisher
三重大学
Publication date
2021-05-14
Material Format
Digital
Capacity, size, etc.
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application/pdf2018年度~2020年度科学研究費補助金(挑戦的研究(萌芽))研究成果報告書18K19474

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Summary, etc.:

正常マウスのCD8+ T細胞エクソソームのがん組織への投与では、がん間質の間葉系細胞傷害は観察されるものの、T細胞の腫瘍浸潤に劇的な改善が見られなかったため、がん細胞に特異性を付与したCAR-T細胞の培養上清から得られるエクソソームを用いた実験を行うこととした。CAR-T細胞エクソソームには、CAR...

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Digital

Material Type
文書・図像類
Author/Editor
瀬尾, 尚宏
Author Heading
瀬尾, 尚宏 セオ, ナオヒロ
Publication, Distribution, etc.
Publication Date
2021-05-14
Publication Date (W3CDTF)
2021-05-14
Alternative Title
Optimization of tumor-infiltrating of cytotoxic T cells using capacity of the anti-mesenchymal tumor stromal cells of CD8+ T cell exosomes
Text Language Code
jpn