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星細胞を標的としたマイクロRNA の強制発現による線維化治療法の開発

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星細胞を標的としたマイクロRNA の強制発現による線維化治療法の開発

Material type
文書・図像類
Author
小川, 智弘
Publisher
近畿大学
Publication date
2011-01-01
Material Format
Digital
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研究種目:若手研究(B); 研究期間:2010~2011; 課題番号:22790666; 研究分野:肝臓病学; 科研費の分科・細目:内科系臨床医学・消化器内科学Research Paperapplication/pdf

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http://kaken.nii.ac.jp/d/r/70448752.ja.html

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研究成果の概要(和文):本研究により星細胞の活性化やコラーゲン産生に重要なマイクロRNAが数種同定された。その中でもcollagen 1A1に結合する可能性の高いmiR-29bに着目した。このマイクロRNAを星細胞で強制発現させると、I型コラーゲンの発現が抑制された。また、miR-29bは、マウス星...

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Digital

Material Type
文書・図像類
Author/Editor
小川, 智弘
Author Heading
Publication, Distribution, etc.
Publication Date
2011-01-01
Publication Date (W3CDTF)
2011-01-01
Alternative Title
Development of liver fibrosis therapy targeting hepatic stellate cells by microRNA
Periodical title
科学研究費補助金研究成果報告書 (2011. )
Pages
1-5