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文書・図像類

包括的エピゲノム解析に基づいた脂肪性肝疾患からの肝発癌予測因子の同定

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包括的エピゲノム解析に基づいた脂肪性肝疾患からの肝発癌予測因子の同定

Material type
文書・図像類
Author
西田, 直生志ほか
Publisher
近畿大学
Publication date
2014-01-01
Material Format
Digital
Capacity, size, etc.
-
NDC
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Note (General):

研究種目:基盤研究(C); 研究期間:2012~2014; 課題番号:24590997; 研究分野:消化器内科; 科研費の分科・細目:Research Paperapplication/pdf

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/d/r/60281755.ja.html

https://kaken.nii.ac.jp/d/r/80359801.ja.html

Detailed bibliographic record

Summary, etc.:

研究成果の概要(和文): 細胞株では酸化的DNA損傷 (8-OHdG)でエピゲノム変異が誘発され, 慢性肝炎組織では異常メチル化を持つ遺伝子数は発癌までの期間と相関した. DNAメチル化の網羅的解析により, ウイルス陰性肝癌では, 加齢や糖尿病が背景肝のエピゲノムに影響し, DNAメチル化を介した発...

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Digital

Material Type
文書・図像類
Author/Editor
西田, 直生志
波多野, 悦朗
Publication, Distribution, etc.
Publication Date
2014-01-01
Publication Date (W3CDTF)
2014-01-01
Alternative Title
Identification of risk factors of hepatocarcinogenesis in fatty liver disease through the comprehensive analysis of epigenetic alterations
Periodical title
科学研究費助成事業研究成果報告書 (2014 )
Pages
1-6