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気道構成細胞の表現型変化に基づいた喘息分子薬理療法

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気道構成細胞の表現型変化に基づいた喘息分子薬理療法

Material type
文書・図像類
Author
久米, 裕昭
Publisher
近畿大学
Publication date
2012-01-01
Material Format
Digital
Capacity, size, etc.
-
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機関番号:34419; 研究種目：基盤研究(C); 研究期間：2010 ～ 2012; 課題番号：22590846; 研究分野：医歯薬学; 科研費の分科・細目：内科系臨床医学・呼吸器内科学Research Paperapplication/pdf

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https://kaken.nii.ac.jp/d/r/50303631.ja.html

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Summary, etc.：

研究成果の概要（和文）： スフィンゴシン１リン酸 (S1P) は喘息の炎症反応によりマスト細胞から放出される。S1P を気道平滑筋に曝露すると2 アドレナリン受容体刺激薬による弛緩作用が減弱した。肺微小血管内皮細胞にS1P を曝露すると接着分子（VCAM-1, ICAM-1）の発現が増強し、好酸球...

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Digital

Material Type
文書・図像類
Title
気道構成細胞の表現型変化に基づいた喘息分子薬理療法
Author/Editor
久米, 裕昭
Author Heading
久米, 裕昭
Publication, Distribution, etc.
近畿大学
Publication Date
2012-01-01
Publication Date (W3CDTF)
2012-01-01
Alternative Title
A molecular pharmacological therapy for asthma based on phenotype changing in the structural cells in airways
Periodical title
科学研究費助成事業研究成果報告書 (2012. )
Pages
1-5