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文書・図像類

反応性代謝物を介する肝障害発現に関与する機能タンパク質の解明

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反応性代謝物を介する肝障害発現に関与する機能タンパク質の解明

Material type
文書・図像類
Author
岩城, 正宏ほか
Publisher
近畿大学
Publication date
2013-01-01
Material Format
Digital
Capacity, size, etc.
-
NDC
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Notes on use

Note (General):

研究種目:基盤研究(C); 研究期間:2011~2013; 課題番号:23590210 ; 研究分野:薬物動態・代謝 ; 科研費の分科・細目:薬学・医療系薬学Research Paperapplication/pdf

Related materials as well as pre- and post-revision versions

http://kaken.nii.ac.jp/d/r/30140346.ja.html

http://kaken.nii.ac.jp/d/r/80411578.ja.html

Detailed bibliographic record

Summary, etc.:

研究成果の概要(和文): ジクロフェナク (DF)の肝障害発現に関わる機能タンパク質として, CYP2C9, UGT2B7, MRP2およびMRP3を取り上げ, siRNAにより各タンパク質機能を低下させた. 実験には, ラット初代培養肝細胞を用い, 機能タンパク質とDFおよびDFのグルクロン酸抱合...

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Digital

Material Type
文書・図像類
Author/Editor
岩城, 正宏
川瀬, 篤史
Publication, Distribution, etc.
Publication Date
2013-01-01
Publication Date (W3CDTF)
2013-01-01
Alternative Title
Involvement of metabolic enzymes and transporters in diclofenac-induced liver injury
Periodical title
科学研究費助成事業研究成果報告書 (2013. )
Pages
1-5