文書・図像類

神経変性疾患の新規原因蛋白p62とユビキリン2の関連と治療的蛋白分解亢進

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神経変性疾患の新規原因蛋白p62とユビキリン2の関連と治療的蛋白分解亢進

Material type
文書・図像類
Author
平野, 牧人
Publisher
近畿大学
Publication date
2016
Material Format
Digital
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研究種目:基盤研究(C); 研究期間:2013~2015; 課題番号:25461297; 研究分野:神経内科; 科研費の分科・細目:Research Paperapplication/pdf

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461297/

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Summary, etc.:

研究成果の概要(和文):本研究は、筋萎縮性側索硬化症[ALS]の原因蛋白ubiquilin2やp62/SQSTM1に関する研究であり、ALS患者と対照者iPS細胞由来の神経細胞を用いた。免疫染色の結果、p62遺伝子変異のある患者細胞の細胞質内に、p62の凝集が認められた。このような細胞質内凝集はAL...

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Digital

Material Type
文書・図像類
Author/Editor
平野, 牧人
Author Heading
Publication, Distribution, etc.
Publication Date
2016
Publication Date (W3CDTF)
2016
Alternative Title
Therapeutic protein degradation and relationship between p62 and ubiquilin 2, new proteins causative for neurodegenerative diseases
Periodical title
科学研究費助成事業研究成果報告書 (2015)
Pages
1-6