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ヒトアルゴノート2タンパクの機能構造に基づくsiRNAの最適化学構造の探索

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ヒトアルゴノート2タンパクの機能構造に基づくsiRNAの最適化学構造の探索

Material type
文書・図像類
Author
藤井, 政幸
Publisher
近畿大学
Publication date
2016
Material Format
Digital
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Note (General):

研究種目:基盤研究(C); 研究期間:2013~2015; 課題番号:25410182; 研究分野:化学; 科研費の分科・細目:Research Paperapplication/pdf

Related materials as well as pre- and post-revision versions

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25410182/

Detailed bibliographic record

Summary, etc.:

研究成果の概要(和文):本研究によりヒトアルゴノート2タンパクの機能構造に基づくsiRNAの化学修飾によりAgo2によるアンチセンス鎖選択の効率を改善することが可能となること、シグナルペプチドとのコンジュゲートにより細胞内局在化の制御が可能となること、両親媒性ペプチドとの複合体により細胞膜透過性の改...

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Digital

Material Type
文書・図像類
Author/Editor
藤井, 政幸
Author Heading
Publication, Distribution, etc.
Publication Date
2016
Publication Date (W3CDTF)
2016
Alternative Title
Exploration of optimized chemical structure of siRNA based on the functional structure of human argonaute 2 protein
Periodical title
科学研究費助成事業研究成果報告書 (2015)
Pages
1-6