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EGFR肺癌と第二世代キナーゼ阻害剤:獲得耐性の網羅的解析と個別化治療の新展開

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EGFR肺癌と第二世代キナーゼ阻害剤:獲得耐性の網羅的解析と個別化治療の新展開

Material type
文書・図像類
Author
小林, 祥久
Publisher
近畿大学
Publication date
2018
Material Format
Digital
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研究種目：若手研究(B); 研究期間：2016～2017; 課題番号：16K19989; 研究分野：呼吸器外科; 科研費の分科・細目：Research Paperapplication/pdf

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19989/

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Summary, etc.：

研究成果の概要（和文）：　EGFR遺伝子変異のある肺がんにはEGFRチロシンキナーゼが劇的に効くが、必ずしも全ての変異に有効ではないことと、一旦効いても必ず耐性を獲得することが問題である。我々は、従来の第1世代EGFR阻害剤では効かないエクソン18の変異に第2世代のアファチニブが効くことを示した。次...

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Digital

Material Type
文書・図像類
Title
EGFR肺癌と第二世代キナーゼ阻害剤:獲得耐性の網羅的解析と個別化治療の新展開
Author/Editor
小林, 祥久
Author Heading
小林, 祥久
Publication, Distribution, etc.
近畿大学
Publication Date
2018
Publication Date (W3CDTF)
2018
Alternative Title
EGFR mutant lung cancer and second generation tyrosine kinase inhibitor: acquired resistance and personalized medicine
Periodical title
科学研究費助成事業研究成果報告書 (2017)
Pages
1-4