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RNA結合蛋白質が細胞シグナルに応答して制御する翻訳とmRNA分解との連携機構

RNA結合蛋白質が細胞シグナルに応答して制御する翻訳とmRNA分解との連携機構

Material type
その他
Author
藤原, 俊伸ほか
Publisher
近畿大学
Publication date
2019
Material Format
Digital
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出版タイプ: NAhttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04745/研究種目:基盤研究(B); 研究期間:2016~2018; 課題番号:16H04745; 研究分野:翻訳制御; 科研費の分科・細目:...

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Summary, etc.:

研究成果の概要(和文):ARE結合タンパク質であるZFP36LやZFL36L1は、標的mRNA上にCCR4-NOT複合体をリクルートし、脱アデニル化を介したmRNA分解を惹起し、遺伝子発現を負に調節する。本研究では、AREを有するInterleukin-6 (IL-6) の3'-UTRを組み込んだレ...

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Digital

Material Type
その他
Author/Editor
藤原, 俊伸
三嶋, 雄一郎
足達, 俊吾
Publication, Distribution, etc.
Publication Date
2019
Publication Date (W3CDTF)
2019
Alternative Title
The coupling mechanism of translation and mRNA degradation regulated by RNA binding protein in response to cell signals
Periodical title
科学研究費助成事業研究成果報告書 (2018)
Pages
1-6