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文書・図像類

睡眠誘発物質合成酵素L-PGDSの基質認識と生成物放出のメカニズムの解明

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睡眠誘発物質合成酵素L-PGDSの基質認識と生成物放出のメカニズムの解明

Material type
文書・図像類
Author
島本, 茂
Publisher
近畿大学
Publication date
2019
Material Format
Digital
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Note (General):

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18868/研究種目:若手研究(B); 研究期間:2016~2018; 課題番号:16K18868; 研究分野:熱力学、構造生物学; 科研費の分科・細目:Research Paper...

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Summary, etc.:

研究成果の概要(和文):リポカリン型プロスタグランジンD合成酵素(L-PGDS)は睡眠物質(PGD2)を合成する酵素であり、睡眠中枢を活性化することで哺乳類の睡眠導入や概日サイクル(体内時計)調節に関与している。従って、L-PGDSをターゲットとした創薬は新規作用機序を持つ睡眠調節薬の開発につながる...

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  • Kindai University Academic Resource Repository

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Digital

Material Type
文書・図像類
Author/Editor
島本, 茂
Author Heading
Publication, Distribution, etc.
Publication Date
2019
Publication Date (W3CDTF)
2019
Alternative Title
substrate-induced product-release mechanism of L-PGDS
Periodical title
科学研究費助成事業研究成果報告書 (2018)
Pages
1-4