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がん化学療法誘発末梢神経障害治療を目指した分子標的薬の応用

がん化学療法誘発末梢神経障害治療を目指した分子標的薬の応用

Material type
その他
Author
椿, 正寛
Publisher
近畿大学
Publication date
2019
Material Format
Digital
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出版タイプ: NAhttps://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18965/研究種目:若手研究(B); 研究期間:2016~2018; 課題番号:16K18965; 研究分野:薬物治療学; 科研費の分科・細目:...

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Summary, etc.:

研究成果の概要(和文):オキサリプラチン及びパクリタキセル誘発末梢神経障害の発症メカニズムについて解析を行い、腰髄部分(lumber4~6)におけるProteinkinaseC(PKC)活性化に基づくERK経路の活性化が関与することを見出した。また、PKCあるいはMEKを阻害する分子標的薬によりER...

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Digital

Material Type
その他
Author/Editor
椿, 正寛
Author Heading
Publication, Distribution, etc.
Publication Date
2019
Publication Date (W3CDTF)
2019
Alternative Title
Application of molecular-targeted drugs for treatment of chemotherapy-induced peripheral neuropathy
Periodical title
科学研究費助成事業研究成果報告書 (2018)
Pages
1-6