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文書・図像類

特異体質性肝障害にアシルCoAチオエステル中間代謝物は関与しているか?

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特異体質性肝障害にアシルCoAチオエステル中間代謝物は関与しているか?

Material type
文書・図像類
Author
岩城, 正宏ほか
Publisher
近畿大学
Publication date
2020
Material Format
Digital
Capacity, size, etc.
-
NDC
-
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Notes on use

Note (General):

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08432/研究種目:基盤研究(C); 研究期間:2017~2019; 課題番号:17K08432; 研究分野:薬物動態学; 科研費の分科・細目:Research Paper...

Detailed bibliographic record

Summary, etc.:

研究成果の概要(和文):非ステロイド性抗炎症薬 (NSAIDs)誘発性の特異体質性肝障害の発症原因の一つとして、肝臓内で生成されるアシルCoAチオエステル体 (NSAID-CoA)に着目し、生合成や化学的合成を試みたが、その生成は確認できなかった。一方で、NSAIDsは微弱ながらもアシルCoA合成酵...

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Digital

Material Type
文書・図像類
Author/Editor
岩城, 正宏
川瀬, 篤史
島田, 紘明
Publication, Distribution, etc.
Publication Date
2020
Publication Date (W3CDTF)
2020
Alternative Title
Involvement of acyl-CoA thioester metabolite in drug-induced idiosyncratic liver injury
Periodical title
科学研究費助成事業研究成果報告書 (2019)
Pages
1-6