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生活習慣に起因する腸管バリア機能の破綻が自己免疫性膵炎の発症に果たす役割の解明

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生活習慣に起因する腸管バリア機能の破綻が自己免疫性膵炎の発症に果たす役割の解明

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文書・図像類
Author
三長, 孝輔
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研究分野：消化器内科学

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Summary, etc.：

本研究では高脂肪食による肥満が自己免疫性膵炎(AIP)の発症に及ぼす効果を検討した。MRL/MpJマウスに普通食または高脂肪食を摂取させた後、poly (I:C) を腹腔内注射しAIPを誘導した。病理学的検討から、高脂肪食摂取による肥満はAIPを悪化させ、膵臓における形質細胞様樹状細胞(pDC)を活...

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Digital

Material Type
文書・図像類
Title
生活習慣に起因する腸管バリア機能の破綻が自己免疫性膵炎の発症に果たす役割の解明
Author/Editor
三長, 孝輔
Author Heading
三長, 孝輔
Alternative Title
The role of lifestyle-induced intestinal barrier dysfunction in the pathogenesis of autoimmune pancreatitis
Periodical title
科学研究費助成事業研究成果報告書(2022)
Text Language Code
jpn
Subject Heading
自己免疫性膵炎
生活習慣病
肥満
形質細胞様樹状細胞
I型インターフェロン
高脂肪食
Target Audience
一般
Note (General)
研究分野：消化器内科学