文書・図像類

治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発

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治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発

Material type
文書・図像類
Author
西田, 升三
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Digital
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研究分野：薬物治療学

Detailed bibliographic record

Summary, etc.：

ヒト慢性骨髄性白血病細胞においてBCR-ABL1阻害薬耐性細胞を樹立し、耐性獲得機序の解析を行い、バイパスシグナル伝達経路活性化が関与することを見出した。さらに、このバイパス経路を阻害する分子標的薬によりBCR-ABL1阻害薬耐性を克服することを明らかにした。以上の結果は、臨床におけるBCR-ABL...

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Digital

Material Type
文書・図像類
Title
治療抵抗性慢性骨髄性白血病における耐性因子の同定と新規耐性克服法の開発
Author/Editor
西田, 升三
Author Heading
西田, 升三
Alternative Title
Identification of resistance factors and development of novel strategy to overcome resistance in treatment-resistant chronic myeloid leukemia
Periodical title
科学研究費助成事業研究成果報告書 (2022)
Text Language Code
jpn
Subject Heading
慢性骨髄性白血病
BCR-ABL1阻害薬
Target Audience
一般
Note (General)
研究分野：薬物治療学