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前立腺癌におけるHDAC阻害剤の免疫調節作用および免疫複合療法への応用の研究

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前立腺癌におけるHDAC阻害剤の免疫調節作用および免疫複合療法への応用の研究

Material type
文書・図像類
Author
坂野, 恵里
Publisher
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Material Format
Digital
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Note (General)：

研究分野：泌尿器腫瘍学

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Summary, etc.：

前立腺癌細胞株において、他癌腫で認めるようなTp53変異の有無によるHDAC阻害剤(vorinostat, entinostat)の感受性の違いは認めなかった。前立腺癌マウスモデルにおいては、HDAC阻害剤は抗腫瘍効果を示し、腫瘍関連マクロファージや制御性T細胞、骨髄由来抑制細胞の各関連遺伝子の発現...

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  • Kindai University Academic Resource Repository

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Digital

Material Type
文書・図像類
Title
前立腺癌におけるHDAC阻害剤の免疫調節作用および免疫複合療法への応用の研究
Author/Editor
坂野, 恵里
Author Heading
坂野, 恵里
Alternative Title
Immunomodulatory effects of HDAC inhibitors for combination immunotherapy in prostate cancer
Periodical title
科学研究費助成事業研究成果報告書 (2022)
Text Language Code
jpn
Subject Heading
前立腺癌
HDAC阻害剤
複合免疫療法
腫瘍免疫微小環境
TP53変異
Target Audience
一般
Note (General)
研究分野：泌尿器腫瘍学