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神経変性疾患における液-液相分離の制御破綻による蛋白質凝集メカニズムの解明

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神経変性疾患における液-液相分離の制御破綻による蛋白質凝集メカニズムの解明

Material type
文書・図像類
Author
永井, 義隆
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Digital
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研究分野:神経内科学

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本研究では、ポリグルタミン(PolyQ)病、筋萎縮性側索硬化症(ALS)などの神経変性疾患における原因蛋白質の液-液相分離(LLPS)の制御破綻による凝集メカニズムの解明を目的として、1)Thio-PolyQとTDP-43-MBPの試験管内実験系を樹立し、両蛋白質のLLPS・凝集を阻害する化合物Xを...

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  • Kindai University Academic Resource Repository

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Digital

Material Type
文書・図像類
Author/Editor
永井, 義隆
Author Heading
Alternative Title
Elucidation of regulation mechanisms of LLPS leading to pathological protein aggregation in neurodegenerative diseases
Periodical title
科学研究費助成事業研究成果報告書 (2023)
Text Language Code
jpn
Target Audience
一般
Note (General)
研究分野:神経内科学