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HIF-1/VHL制御系による造血幹細胞維持機構の解明と幹細胞増幅

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HIF-1/VHL制御系による造血幹細胞維持機構の解明と幹細胞増幅

Material type
文書・図像類
Author
田久保, 圭誉
Publisher
-
Publication date
2010
Material Format
Digital
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Note (General)：

type:text造血幹細胞(HSC)はニッチと呼ばれる特殊な微小環境で維持される。本課題ではHSCは骨髄内骨膜近傍領域において低酸素状態で細胞周期を静止期にとどめていることを見出した。また、こうした性質の維持のためには低酸素応答因子HIF-1alphaとその蛋白を破壊するために必要なE3ユビキチン...

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Digital

Material Type
文書・図像類
Title
HIF-1/VHL制御系による造血幹細胞維持機構の解明と幹細胞増幅
Author/Editor
田久保, 圭誉
Author Heading
田久保, 圭誉
Publication Date
2010
Publication Date (W3CDTF)
2010
Alternative Title
HIF-1/VHL セイギョケイ ニ ヨル ゾウケツ カンサイボウ イジ キコウ ノ カイメイ ト カンサイボウ ゾウフク
HIF-1/VHL seigyokei ni yoru zoketsu kansaibo iji kiko no kaimei to kansaibo zofuku
Molecular mechanisms for hematopoietic stem cells by HIF-1/VHL regulatory system
Periodical title
科学研究費補助金研究成果報告書
Text Language Code
jpn
Subject Heading
造血幹細胞,低酸素,静止期,老化