Prediction of potentially unstable electrical activity during embryonic development of rodent ventricular myocytes

Material type: 文書・図像類

Author: 大久保, 周子

Publisher: 慶應義塾大学湘南藤沢学会

Publication date: 2012

Material Format: Digital

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Note (General)：: type:textEarly embryonic rodent ventricular cells exhibit spontaneous action potential (AP), which disappears in later developmental stages. In this s...

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Material Type: 文書・図像類
Title: Prediction of potentially unstable electrical activity during embryonic development of rodent ventricular myocytes
Author/Editor: 大久保, 周子
Author Heading: 大久保, 周子
Publication, Distribution, etc.: 慶應義塾大学湘南藤沢学会
Publication Date: 2012
Publication Date (W3CDTF): 2012
Periodical title: 生命と情報
No. or year of volume/issue: 19
Volume: 19
Pages: 89-98
Text Language Code: eng
Subject Heading: computer simulation,ion channels,ventricular cells,development,electrophysiology
Target Audience: 一般
Note (General): type:text
Early embryonic rodent ventricular cells exhibit spontaneous action potential (AP), which disappears in later developmental stages. In this study, we used 2 mathematical models —the Kyoto and Luo-Rudy models— to overview the functional landscape of developmental changes in embryonic ventricular cells and predict potentially unstable APs. By switching the relative activities of 9 ionic components, of 512 representative combinations, the Kyoto model predicted 208 combinations to result in quiescent cells and 160 combinations to have regular spontaneous APs. The remaining 144 combinations were predicted to be potentially unstable, resulting from combinations of funny current (If), inward rectifier current (Ik1), sustained inward current (Ist), L-type Ca2+ current (IcaL), and Na+ current (INa). The Luo-Rudy model was used to verify the results. Based on these results, we suggest that sequential switches in the relative activities of INa, If, and Ik1 enable ventricular cells to avoid unstable patterns.
慶應義塾大学湘南藤沢キャンパス先端生命科学研究会 2012年度学生論文集卒業論文ダイジェスト
identifier:SFC-RM2013-001
identifier:請求記号: 090@KE1@179-19
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ