菌状息肉症モデルマウスの作製と表皮浸潤・転移機構の解析

Material type: 文書・図像類

Author: 福田, 桂太郎

Publisher: -

Publication date: 2014

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: type:text菌状息肉症(MF)は表皮向性を示し, interface dermatitis(ID)やPautrier微小膿瘍(PM)を認める。本研究はMFマウスの作製, MFの表皮浸潤機構の解明を目的に実施した。我々はデスモグレイン3を認識するTCR(H1), MFのInk4a/Arf(がん抑...

Related materials as well as pre- and post-revision versions

科研費研究者番号 : 60464848

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Keio Associated Repository of Academic resources
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Keio Associated Repository of Academic resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 菌状息肉症モデルマウスの作製と表皮浸潤・転移機構の解析
Author/Editor: 福田, 桂太郎
Author Heading: 福田, 桂太郎
Publication Date: 2014
Publication Date (W3CDTF): 2014
Alternative Title: キンジョウソクニクショウモデルマウスノサクセイトヒョウヒシンジュン・テンイキコウノカイセキ
Kinjo sokunikusho moderu mausu no sakusei to hyohi shinjun teni kiko no kaiseki
The study of mechanism of epidermotropism and metastasis of mycosis fungoides by establishing mouse mycosis fungoides model
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 菌状息肉症,Pautrier微小膿瘍,表皮抗原認識,C-MYC,INK4A/ARF
Target Audience: 一般
Note (General): type:text
菌状息肉症(MF)は表皮向性を示し, interface dermatitis(ID)やPautrier微小膿瘍(PM)を認める。本研究はMFマウスの作製, MFの表皮浸潤機構の解明を目的に実施した。我々はデスモグレイン3を認識するTCR(H1), MFのInk4a/Arf(がん抑制遺伝子)変異, c-Myc(がん遺伝子)をCD4+T細胞に導入, Rag2欠損マウスに移植し, ID, PMをきたすMFマウスの作製に成功した。Ink4a/Arf変異・H1導入CD4+細胞はPMを形成せず, Ink4a/Arf変異・c-Myc導入CD4+T細胞はPMを形成した。PMの形成にはc-Mycが必要であることが示唆された。 Mycosis fungoides (MF) is a cutaneous T cell lymphoma of CD4+ T cells that show epidermotropism. It is characterized by interface dermatitis (ID) and Pautrier's microabscess (PM), a clustering of MF cells in the epidermis. This project was conducted to establish MF model mouse that recapitulate histopathology of MF and to clarify the mechanism of the development of PM. Since mutation in INK4A/ARF (tumor suppressor gene) and overexpression of C-MYC (oncogene) are associated in human MF, we isolated CD4+T cells from Ink4/Arf-/- mice and retrovirally transduced c-Myc and desmoglein 3 specific TCR (H1) that induces ID. T cells were then adoptively transferred into Rag2-/- mice, which lead to the development of ID and PM that recapitulated MF. In addition, transfer of Ink4/Arf-/- CD4+T cells transduced with c-Myc developed PM whereas transfer of Ink4/Arf-/- CD4+T cells transduced with H1 did not develop PM. Our results suggest that oncogene c-Myc is essential for the development of PM.
研究種目 : 若手研究(B) 研究期間 : 2013～2014 課題番号 : 25860967 研究分野 : 皮膚科学
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 60464848
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ