好中球由来のMMP9を介した急性大動脈解離の発症機構

Material type: 文書・図像類

Author: 清水, 良子

Publisher: -

Publication date: 2015

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: type:text大動脈解離(AAD)患者ではMMP9血中濃度が上昇し, 患部血管手術標本ではMMP9が好中球と一致して上昇していた。BAPNを前投与したマウスにAngIIを投与してAADを惹起させるマウスモデルの検討から, MMP9阻害剤投与でAAD発症率が低下し, MMP9ノックアウトマウスでは...

Related materials as well as pre- and post-revision versions

科研費研究者番号 : 30348643

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Keio Associated Repository of Academic resources
Digital
You can check the holdings of institutions and databases with which 学術機関リポジトリデータベース（IRDB）（機関リポジトリ） is linked at the site of 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）.
Keio Associated Repository of Academic resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 好中球由来のMMP9を介した急性大動脈解離の発症機構
Author/Editor: 清水, 良子
Author Heading: 清水, 良子
Publication Date: 2015
Publication Date (W3CDTF): 2015
Alternative Title: コウチュウキュウユライノ MMP9 オカイシタキュウセイダイドウミャクカイリノハツショウキコウ
Kochukyu yurai no MMP9 o kaishita kyusei daidomyaku kairi no hatsusho kiko
Neutrophil-derived matrix metalloproteinase 9 triggers acute aortic dissection
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 大動脈解離,MMP9
Target Audience: 一般
Note (General): type:text
大動脈解離(AAD)患者ではMMP9血中濃度が上昇し, 患部血管手術標本ではMMP9が好中球と一致して上昇していた。BAPNを前投与したマウスにAngIIを投与してAADを惹起させるマウスモデルの検討から, MMP9阻害剤投与でAAD発症率が低下し, MMP9ノックアウトマウスではAADがほぼ完全に抑制された。好中球除去もAADの発症は減少した。AAD患部血管では酸化ストレスが有意に亢進し, 酸化ストレス阻害剤投与でマウスAAD発症率とMMP9産生が減少した。血管平滑筋細胞と好中球の共培養から, 血管平滑筋細胞をAngIIで刺激すると好中球のMMP9産生が亢進し, 酸化ストレス阻害剤で抑制された。 We found MMP9 was elevated significantly in blood samples from acute aortic dissection (AAD) patients. Using a novel AAD model by infusing angiotensin II to immature mice that had been received a lysyl oxidase inhibitor, we found the incidence of AAD was reduced significantly following the administration of an MMP inhibitor and was almost blocked completely in MMP9 (-/-) mice. Neutrophil depletion also significantly decreased the incidence of AAD. Oxidative stress is upregulated in the AAD aorta and an oxidative stress inhibitor reduced the incidence of AAD and the production of MMP9. Coculture experiments using vascular smooth muscle cells and neutrophils revealed the upregulation of MMP9 by neutrophils following AngII stimulation of VSMCs, which was blocked by ROS inhibitor. These data suggest that AAD is initiated by neutrophils that have infiltrated the aortic intima and released MMP9 in response to angiotensin II and the following oxidative stress upregulation.
研究種目 : 若手研究(B) 研究期間 : 2013～2015 課題番号 : 25870718 研究分野 : 血管医学
Source: https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/download.php?koara_id=KAKEN_25870718seika
https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/download.php?koara_id=KAKEN_25870718seika
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 30348643
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ