メラノプシンが非視覚応答を担う分子機構の解明

Material type: 文書・図像類

Author: 羽鳥, 恵

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Publication date: 2015

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Note (General)：: type:text哺乳類の目の数%の網膜神経節細胞には青色光感受性の光受容タンパク質メラノプシンが発現しており, 概日時計の位相調節や瞳孔の開閉などの非視覚応答を制御する。メラノプシンは桿体・錐体の光受容体とは異なり, 無脊椎動物オプシンに類似していると考えられている。網膜の視覚応答・非視覚応答を理...

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科研費研究者番号 : 90590472

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Material Type: 文書・図像類
Title: メラノプシンが非視覚応答を担う分子機構の解明
Author/Editor: 羽鳥, 恵
Author Heading: 羽鳥, 恵
Publication Date: 2015
Publication Date (W3CDTF): 2015
Alternative Title: メラノプシンガヒシカクオウトウオニナウブンシキコウノカイメイ
Meranopushin ga hishikaku oto o ninau bunshi kiko no kaimei
Molecular mechanism of melanopsin to induce non-image forming responses
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: メラノプシン,概日リズム,網膜
Target Audience: 一般
Note (General): type:text
哺乳類の目の数%の網膜神経節細胞には青色光感受性の光受容タンパク質メラノプシンが発現しており, 概日時計の位相調節や瞳孔の開閉などの非視覚応答を制御する。メラノプシンは桿体・錐体の光受容体とは異なり, 無脊椎動物オプシンに類似していると考えられている。網膜の視覚応答・非視覚応答を理解するために, 本研究ではランダムミュータジェネシスおよび特定の領域を狙うメラノプシン変異体作製を同時並行させた。哺乳類培養細胞にメラノプシン変異体を発現させ, 青色光照射によるカルシウム濃度の変化, つまりメラノプシン光応答をin vitroで測定し, 数種類の光応答変異体を単離した。 Melanopsin photopigment expressed in intrinsically photosensitive retinal ganglion cells plays a crucial role in the adaptation of mammals to ambient light environment through both image-forming and non-image-forming visual responses. The melanopsin-expressing retinal ganglion cells are structurally and functionally distinct from classical rod/cone photoreceptors and have unique properties, including single-photon response, long response latency, photon integration over time, and slow deactivation. To understand the molecular property of melanospin, I generated various mutant versions of melanopsin, and these proteins were expressed in mammalian cells. Blue light-dependent increases in cytosolic calcium were monitored. By using this assay system, several of mutant melanopsin were obtained to show in vitro response difference compared to wild type melanopsin, and the effect of these mutant melanopsin on non-image forming responses will be evaluated in vivo in mice.
研究種目 : 研究活動スタート支援研究期間 : 2014～2015 課題番号 : 26891022 研究分野 : 神経科学
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 90590472
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ