重度外傷・熱傷患者における免疫学的モニタリングによる臓器不全発症の予知

Material type: 文書・図像類

Author: 関根, 和彦

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Publication date: 2015

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Note (General)：: type:text重度熱傷・外傷患者において白血球フェノタイプ(LP)解析により感染合併症や臓器不全が予知できるかを検討した。重度外傷熱傷患者16人と健常人5人を対象としてLP解析した。解析LP : CD4/8/11c/16b/25/36/66b/123/127/161, TLR-2/4, CCR-...

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科研費研究者番号 : 90296715

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Material Type: 文書・図像類
Title: 重度外傷・熱傷患者における免疫学的モニタリングによる臓器不全発症の予知
Author/Editor: 関根, 和彦
Author Heading: 関根, 和彦
Publication Date: 2015
Publication Date (W3CDTF): 2015
Alternative Title: ジュウドガイショウ・ネッショウカンジャニオケルメンエキガクテキモニタリングニヨルゾウキフゼンハツショウノヨチ
Judo gaisho nessho kanja ni okeru menekigakuteki monitaringu ni yoru zoki fuzen hatsusho no yochi
Anticipation of organ dysfunction by immunological monitoring in severe trauma and burns
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 免疫,侵襲,臓器不全,白血球,フェノタイプ解析
Target Audience: 一般
Note (General): type:text
重度熱傷・外傷患者において白血球フェノタイプ(LP)解析により感染合併症や臓器不全が予知できるかを検討した。重度外傷熱傷患者16人と健常人5人を対象としてLP解析した。解析LP : CD4/8/11c/16b/25/36/66b/123/127/161, TLR-2/4, CCR-2/4/5, CXCR-3, CRTh2。熱傷患者では, 外傷患者よりもCCR5, CXCR3, CD68, CD123が低下した。熱傷患者では, 感染発症後にCCR5が増加し, CD25が低下した。感染・臓器障害発症後にはCCR5, CXCR3, CCR2, CD11cが増加した。熱傷後のTh1再上昇は感染合併症や臓器不全の発症が示唆された。 Sepsis-induced organ dysfunction (SIOD) has been considered to be involved in leukocyte phenotypic changes in severely injured and burned patients. Our question is whether SIOD can be predicted by leukocyte immunophenotyping or not in these trauma or burned patients, using a new array method we developed. Among 16 patients with trauma/burns and 5 healthy volunteers, we analyzed the leukocyte phenotypes including CD4/8/11c/16b/25/36/66b/123/127/161, Toll like receptor (TLR)-2/4, CC-Chemokine receptor (CCR)-2/4/5, CXC-Chemokine receptor (CXCR)-3, and CRTh2. In burned patients, phenotypes were lower not only in CCR5 and CXCR3 than those in both trauma and healthy subjects, and also in CD68 and CD123 than those in trauma, whereas phenotypes in Th1 (CCR5, CXCR3) and monocytes /dendritic cells (CCR2, CD11c) were increased. Based on these results, re-increase of Th1 phenotypes may predict infectious complications or organ dysfunction after burn insults.
研究種目 : 基盤研究(C)(一般) 研究期間 : 2012～2015 課題番号 : 24592748 研究分野 : 救急医学
Source: https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/download.php?koara_id=KAKEN_24592748seika
https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/download.php?koara_id=KAKEN_24592748seika
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 90296715
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ