胆道領域がんの発がん・増殖・進展にかかわる分子機構の解明と臨床治療への応用

Material type: 文書・図像類

Author: 尾島, 英知

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Publication date: 2016

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Note (General)：: type:text多数の胆道領域がんバイオリソースを用いて, 発がん・増殖・進展に関わる分子機構の解明を行った。その結果, 腫瘍発生部位に関連する4候補遺伝子が見いだされ, 免疫組織学的検討で腫瘍存在部位に一致した発現傾向を得た。腫瘍進展因子IDCC(Intraductal carcinoma co...

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Material Type: 文書・図像類
Title: 胆道領域がんの発がん・増殖・進展にかかわる分子機構の解明と臨床治療への応用
Author/Editor: 尾島, 英知
Author Heading: 尾島, 英知
Publication Date: 2016
Publication Date (W3CDTF): 2016
Alternative Title: タンドウリョウイキガンノハツガン・ゾウショク・シンテンニカカワルブンシキコウノカイメイトリンショウチリョウエノオウヨウ
Tando ryoiki gan no hatsugan zoshoku shinten ni kakawaru bunshi kiko no kaimei to rinsho chiryo eno oyo
Investigation of molecular mechanisms involved in carcinogenesis, proliferation and progression of biliary tract carcinoma and its application to clinical treatment
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 胆道領域がん,細胞株,新鮮切除検体,遺伝子発現,データベース,免疫染色,前臨床試験
Target Audience: 一般
Note (General): type:text
多数の胆道領域がんバイオリソースを用いて, 発がん・増殖・進展に関わる分子機構の解明を行った。その結果, 腫瘍発生部位に関連する4候補遺伝子が見いだされ, 免疫組織学的検討で腫瘍存在部位に一致した発現傾向を得た。腫瘍進展因子IDCC(Intraductal carcinoma component ;上皮内がん成分)に関連する50候補遺伝子の解析では, IDCC陰性群(高悪性度群)に高く発現している遺伝子の多くは転移・浸潤に関連した遺伝子であることが判明し, 臨床病理組的解析結果の裏付けとなった。さらに, これら遺伝子を標的にした新規抗がん剤の前臨床試験も可能なin vitro assay系も確立された。 We have elucidated the molecular mechanisms of carcinogenesis, proliferation and progression of biliary tract carcinoma (BTC) using numerous BTC-related bio-resources. As a result, four candidate genes associated with different sites of tumor locations were found and immunohistochemical study using surgical specimens confirmed the consistency of their expression with the tumor existing sites. Analysis of 50 candidate genes associated with IDCC (Intraductal Carcinoma Component) as one of the histopathological BTC spreading and malignancy factors revealed that many highly expressed genes in the tumor group without IDCC (high-grade group) were involved in tumor malignancy related with metastasis or invasion. This data supported the clinicopathological features of IDCC. Furthermore, we have established in vitro assay system of BTC that enables preclinical study and appropriates parameters for novel anticancer drugs which targeting the above genes.
研究種目 : 基盤研究(C)(一般) 研究期間 : 2014～2016 課題番号 : 26460501 研究分野 : 医歯薬学 PDFファイルは改訂版に差し替え (2022.3.15)
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Related Material: 科研費研究者番号 : 80342905
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