iPS細胞を用いた新規動脈硬化抑制因子の探索

Material type: 文書・図像類

Author: 楠本, 大

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Publication date: 2016

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Note (General)：: type:text動脈硬化の進展には糖尿病などの環境リスク因子が大きな影響を及ぼすが, 患者の遺伝的要因も同様に重要である。中には大変稀であるが, 動脈硬化リスクが非常に高いにもかかわらず動脈硬化の進展が全く認められない患者(抗動脈硬化患者)が存在する。そのような患者は内因性の非常に強い抗動脈硬化機...

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科研費研究者番号 : 70571727

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Material Type: 文書・図像類
Title: iPS細胞を用いた新規動脈硬化抑制因子の探索
Author/Editor: 楠本, 大
Author Heading: 楠本, 大
Publication Date: 2016
Publication Date (W3CDTF): 2016
Alternative Title: iPS サイボウオモチイタシンキドウミャクコウカヨクセイインシノタンサク
iPS saibo o mochiita shinki domyaku koka yokusei inshi no tansaku
The exploratory research to investigate the novel anti-atherosclerotic factor using iPS cells
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 動脈硬化,iPS細胞,血管内皮細胞
Target Audience: 一般
Note (General): type:text
動脈硬化の進展には糖尿病などの環境リスク因子が大きな影響を及ぼすが, 患者の遺伝的要因も同様に重要である。中には大変稀であるが, 動脈硬化リスクが非常に高いにもかかわらず動脈硬化の進展が全く認められない患者(抗動脈硬化患者)が存在する。そのような患者は内因性の非常に強い抗動脈硬化機構を有しているはずである。本研究では抗動脈硬化患者より作成した疾患iPS細胞を用いて内因性の抗動脈機構を解明し, 根治を目指した新規治療法開発を行いたいと考えた。 Throughout our lives, we are exposed to cellular stress, which causes age-related diseases, such as metabolic syndromes, atherosclerosis, and cancer. Although we have evolved several innate protective mechanisms from cellular stress, the damage is often cumulative and irreversible. However, in rare cases, patients with strong chronic stress such as uncontrolled diabetes, exhibit minimal organ damage, suggesting that they would have strong innate protective mechanisms. Although there are several methods of genetic analysis, including genome-wide association study and exome sequencing, the vascular protective mechanisms are still unknown. In this study, we used the endothelial cells (ECs) derived from induced pluripotent stem cells (iPSCs) of severe diabetic patients with mild atherosclerosis to examine these innate protective mechanisms and explore a molecular target, to propose a novel vascular protective mechanism against cellular stresses.
研究種目 : 若手研究(B) 研究期間 : 2014～2016 課題番号 : 26860583 研究分野 : 循環器内科
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 70571727
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ