尿路上皮癌における抗がん剤耐性下の癌微小環境変化の解明

Material type: 文書・図像類

Author: 丹羽, 直也

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Publication date: 2016

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Note (General)：: type:text尿路上皮癌細胞株5637とCDDP耐性尿路上皮癌細胞株5637PR にTNF-alpha induced protein (TNFAIP2)をノックダウン・過剰発現させたところ, TNFAIP2の発現上昇・低下に伴い上皮間葉転換関連因子の発現抑制・亢進が認められた。上部尿路上皮癌の...

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科研費研究者番号 : 40626743

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Material Type: 文書・図像類
Title: 尿路上皮癌における抗がん剤耐性下の癌微小環境変化の解明
Author/Editor: 丹羽, 直也
Author Heading: 丹羽, 直也
Publication Date: 2016
Publication Date (W3CDTF): 2016
Alternative Title: ニョウロジョウヒガンニオケルコウガンザイタイセイカノガンビショウカンキョウヘンカノカイメイ
Nyoro johigan ni okeru koganzai taiseika no gan bisho kankyo henka no kaimei
The importance of regulation of the tumor microenvironment in cisplatin-resistant urothelial carcinoma
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 尿路上皮癌,癌微小環境,上皮間葉転換,シスプラチン,抗癌剤耐性
Target Audience: 一般
Note (General): type:text
尿路上皮癌細胞株5637とCDDP耐性尿路上皮癌細胞株5637PR にTNF-alpha induced protein (TNFAIP2)をノックダウン・過剰発現させたところ, TNFAIP2の発現上昇・低下に伴い上皮間葉転換関連因子の発現抑制・亢進が認められた。上部尿路上皮癌の臨床検体を用いてTNFAIP2の免疫組織学的評価では, TNFAIP2の高発現は有意に予後と関連していた。更にTNFAIP2の発現上昇・低下に伴いIn vitroにおいて癌細胞の浸潤能が亢進・抑制されることが確認され, TNFAIP2を介した癌微小環境の制御の重要性並びに新規治療標的となりうる可能性が示唆された。 Knockdown and overexpression of TNF-alpha induced protein 2 (TNFAIP2) in 5637 and its subline 5637PR with acquired platinum resistance resulted in suppression and overexpression of epithelial-mesenchymal transition related proteins, respectively. Immunohistochemical analysis in surgical specimens revealed that the expression of TNFAIP2 is significantly associated with oncologic outcome in patients with urothelial carcinoma. Moreover, overexpression and suppression of TNFAIP2 resulted in promotion and inhibition of cancer cells, respectively. These results suggested the importance of the regulation of the tumor microenvironment by targeting TNFAIP2 and its potential as a new therapeutic target.
研究種目 : 若手研究(B) 研究期間 : 2015～2016 課題番号 : 15K20110 研究分野 : 尿路悪性腫瘍
Source: https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/download.php?koara_id=KAKEN_15K20110seika
https://koara.lib.keio.ac.jp/xoonips/modules/xoonips/download.php?koara_id=KAKEN_15K20110seika
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 40626743
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
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Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ