インジウム曝露による腎肝への影響に関する疫学研究

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Author: 中野, 真規子ほか

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Publication date: 2018

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Note (General)：: type:text本研究はIn曝露作業者の腎/肝の慢性影響を検討した。参加者の平均年齢43歳、血清In濃度(In-S)5.0ng/ml(範囲<0.1-45.2)、KL-6 403U/ml(範囲143-1940)、参加者をIn-S別4群(低・中・高・超高濃度群:In-S<1, 1≦In-S<3, 3≦...

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科研費研究者番号 : 70384906

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Material Type: 文書・図像類
Title: インジウム曝露による腎肝への影響に関する疫学研究
Author/Editor: 中野, 真規子
大前, 和幸
田中, 昭代
平田, 美由紀
岩澤, 聡子
Author Heading: 中野, 真規子
大前, 和幸
田中, 昭代
平田, 美由紀
岩澤, 聡子
Publication Date: 2018
Publication Date (W3CDTF): 2018
Alternative Title: インジウムバクロニヨルジンカンエノエイキョウニカンスルエキガクケンキュウ
Injiumu bakuro ni yoru jinkan eno eikyō ni kansuru ekigaku kenkyū
Chronic effects on the kidneys and liver in indium-exposed workers
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: インジウム,腎,肝
Target Audience: 一般
Note (General): type:text
本研究はIn曝露作業者の腎/肝の慢性影響を検討した。参加者の平均年齢43歳、血清In濃度(In-S)5.0ng/ml(範囲<0.1-45.2)、KL-6 403U/ml(範囲143-1940)、参加者をIn-S別4群(低・中・高・超高濃度群:In-S<1, 1≦In-S<3, 3≦In-S<20, 20≦In-S)に分類した。腎癌罹患はなく、In-SとALP(r=0.331)、In-SとシスタチンC(r=0.446)の間に弱い相関を認め、In-SとシスタチンCの所見率との間に量反応関係の傾向を認めたが、年齢調整後関連はなくなった。高/超高濃度群のn数が少ないため、さらなる検討が必要である。 In this study, we examined chronic effects on the kidneys and liver in indium (In)-exposed workers. The average age of the participants (n = 62) was 43 years, their In concentration in serum (In-S) was 5.0 ng/ml (range, <0.1-45.2), and their Krebs von den Lungen-6 (KL-6) was 403 U/ml (range, 143-1940). We divided the subjects into 4 groups according to In-S (Low, Medium, High and Very High groups: In-S<1, 1≦In-S<3, 3≦In-S<20, 20≦In-S, respectively) and compared among the 4 groups. Workers in the Low and Medium groups accounted for 79% of participants. There were no incidents of renal cancer, and there was a weak correlation between In-S and alkaline phosphatase (r=0.331) and Cystatin C (r=0.446). There was a dose-relationship between In-S and Cystatin C, however the relationship was no significant after adjusting for age. Further study is necessary to evaluate chronic effects on the kidneys and liver in the High and Very High In-S groups.
研究種目 : 基盤研究 (C) (一般) 研究期間 : 2016～2018 課題番号 : 16K09107 研究分野 : 産業疫学
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 70384906
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ