耐性菌感染症の克服を目指した抗菌薬個別最適化投与法の構築

Material type: 文書・図像類

Author: 松元, 一明

Publisher: -

Publication date: 2020

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: type:textフロモキセフとラタモキセフは基質特異性拡張型β-ラクタマーゼ（ESBL）産生大腸菌に抗菌活性を示すため注目されているが、PK/PD解析が実施されておらず臨床応用に至っていない。そこで、ESBL産生大腸菌に対するフロモキセフとラタモキセフのPK/PDパラメータを明らかにすることを目的...

Related materials as well as pre- and post-revision versions

科研費研究者番号 : 60733160

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Keio Associated Repository of Academic resources
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Keio Associated Repository of Academic resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 耐性菌感染症の克服を目指した抗菌薬個別最適化投与法の構築
Author/Editor: 松元, 一明
Author Heading: 松元, 一明
Publication Date: 2020
Publication Date (W3CDTF): 2020
Alternative Title: タイセイキンカンセンショウノコクフクオメザシタコウキンヤクコベツサイテキカトウヨホウノコウチク
Taiseikin kansenshō no kokufuku o mezashita kōkin'yaku kobetsu saitekika tōyohō no kōchiku
Development of individually optimized dosing regimen for antimicrobial agents aiming at overcoming antimicrobial-resistant bacterial infections
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: ESBL産生大腸菌,フロモキセフ,セフメタゾール,PK/PD
Target Audience: 一般
Note (General): type:text
フロモキセフとラタモキセフは基質特異性拡張型β-ラクタマーゼ（ESBL）産生大腸菌に抗菌活性を示すため注目されているが、PK/PD解析が実施されておらず臨床応用に至っていない。そこで、ESBL産生大腸菌に対するフロモキセフとラタモキセフのPK/PDパラメータを明らかにすることを目的として研究を行った。In vitro試験で、両剤共に時間依存的な抗菌活性を示した。好中球減少大腿部感染マウスモデルを用いてPK/PD解析を実施した結果、time above MICに最も相関することが示され、最大殺菌効果である1 log10 killを達成するための目標値はそれぞれ35.1%と69.6%であった。 Although flomoxef and cefmetazole has attracted substantial attention as an antibiotic against extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-producing E. coli), the pharmacokinetics/pharmacodynamics (PK/PD) characteristics of flomoxef and cefmetazole against ESBL-producing E. coli is unclear. The aim of this study was to determine the PK/PD index of flomoxef and cefmetazole against ESBL-producing E. coli. Time-kill curves exhibited time-dependent activities. In neutropenic murine thigh infection experiments, the antibacterial activities of flomoxef and cefmetazole correlated with the time that the free drug concentration remaining above the minimum inhibitory concentration (MIC) (fT>MIC) The target values of fT>MIC for 1 log10 kill reduction were 35.1% for flomoxef and 69.6% for cefmetazole. Thus, fT>MIC is the most significant PK/PD index of flomoxef and cefmetazole against ESBL-producing E. coli and its target values are ≧40% and 70%, respectively.
研究種目 : 基盤研究 (C) (一般) 研究期間 : 2018～2020 課題番号 : 18K06795 研究分野 : 医療薬学
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 60733160
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ