マイクロ曲面操作で切り拓く細胞の形状認識機構と接着界面力学のメカノバイオロジー

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Author: 山下, 忠紘

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Publication date: 2020

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Note (General)：: type:text本研究は、マイクロ曲面上で血管平滑筋細胞が示す挙動の詳細を観察するために、培養面の曲率を操作可能な新しい細胞培養技術の開発に取り組んだ。変形する曲面の上で血管平滑筋細胞を培養し、培養面の曲率の変化に対する細胞の配向追従挙動の観察を初めて実現した。さらに細胞培養系に改良を施すことで、...

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科研費研究者番号 : 00827339

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Material Type: 文書・図像類
Title: マイクロ曲面操作で切り拓く細胞の形状認識機構と接着界面力学のメカノバイオロジー
Author/Editor: 山下, 忠紘
Author Heading: 山下, 忠紘
Publication Date: 2020
Publication Date (W3CDTF): 2020
Alternative Title: マイクロキョクメンソウサデキリヒラクサイボウノケイジョウニンシキキコウトセッチャクカイメンリキガクノメカノバイオロジー
Maikuro kyokumen sōsa de kirihiraku saibō no keijō ninshiki kikō to setchaku kaimen rikigaku no mekanobaiorojī
Development of microdevices to investigate cellular curvature-sensing mechanisms based on mechanobiology of adhesion interface
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 曲率,血管平滑筋細胞,マイクロデバイス
Target Audience: 一般
Note (General): type:text
本研究は、マイクロ曲面上で血管平滑筋細胞が示す挙動の詳細を観察するために、培養面の曲率を操作可能な新しい細胞培養技術の開発に取り組んだ。変形する曲面の上で血管平滑筋細胞を培養し、培養面の曲率の変化に対する細胞の配向追従挙動の観察を初めて実現した。さらに細胞培養系に改良を施すことで、曲面上で細胞が発する張力の計測に取り組み、培養面の凸形状が平滑筋細胞の表現型を収縮型に誘導することを示唆する結果を得た。 We developed a new micro-cell-culture platform that enables temporal change of curvature of the cell-adhering surface, to investigate the detail of unique behaviours that vascular smooth muscle cells (VSMCs) show on curved surfaces at the scale of several hundred micrometres. To prove the concept, VSMCs were exposed to a sudden change of the curvature of the cell-adhering plane, and their response in orientation was monitored, showing their acute sensitivity to the surface curvature. Additionally, cellular contractility was measured by improving the controlling system. These observations on VSMCs on curved surfaces suggest that the curvature of the cell-adhering plane has a significant impact on the phenotype of VSMCs.
研究種目 : 若手研究研究期間 : 2019～2020 課題番号 : 19K20679 研究分野 : メカノバイオロジー
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 00827339
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ