新型コロナウイルス感染後の肺及び他臓器の長期後遺症の実態解明と基盤研究

Material type: 文書・図像類

Author: 石井, 誠

Publisher: 慶應義塾大学

Publication date: 2021

Material Format: Digital

Capacity, size, etc.: -

NDC: -

View All

Notes on use

Note (General)：: type:text新型コロナウイルス感染症(COVID-19)は、2019 年12 月に中国で原因不明の肺炎として報告されて以降、全世界に拡大した。国内では第6波が終息しつつあるが再流行の兆しが見えており、今後も流行を繰り返す可能性が高い。近年COVID-19 に罹患後に長期間に及び全身倦怠感、呼吸...

Search by Bookstore

Holdings of Libraries in Japan

This page shows libraries in Japan other than the National Diet Library that hold the material.

List of Cooperating Institutions and Databases

Please contact your local library for information on how to use materials or whether it is possible to request materials from the holding libraries.

other

Keio Associated Repository of Academic resources
Digital
You can check the holdings of institutions and databases with which Institutional Repositories DataBase(IRDB)(Institutional Repository) is linked at the site of Institutional Repositories DataBase(IRDB)(Institutional Repository).
Keio Associated Repository of Academic resources

Search by Bookstore

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 文書・図像類
Title: 新型コロナウイルス感染後の肺及び他臓器の長期後遺症の実態解明と基盤研究
Author/Editor: 石井, 誠
Author Heading: 石井, 誠
Publication, Distribution, etc.: 慶應義塾大学
Publication Date: 2021
Publication Date (W3CDTF): 2021
Alternative Title: シンガタコロナウイルスカンセンゴノハイオヨビタゾウキノチョウキコウイショウノジッタイカイメイトキバンケンキュウ
Shingata koronauirusu kansengo no hai oyobi tazōki no chōki kōishō no jittai kaimei to kiban kenkyū
Elucidation of long-term sequelae in the lungs and other organs after infection with SARS-CoV-2
Periodical title: 学事振興資金研究成果実績報告書
Text Language Code: jpn
eng
Target Audience: 一般
Note (General): type:text
新型コロナウイルス感染症(COVID-19)は、2019 年12 月に中国で原因不明の肺炎として報告されて以降、全世界に拡大した。国内では第6波が終息しつつあるが再流行の兆しが見えており、今後も流行を繰り返す可能性が高い。近年COVID-19 に罹患後に長期間に及び全身倦怠感、呼吸困難、頭痛、嗅覚・味覚障害など、種々の後遺症が報告されている。特にCOVID-19 による肺炎後にウイルスは消失した後も肺の線維化が進行し、低肺機能や、呼吸困難の症状が持続することが報告されているが、日本の実態は不明である。本研究では、慶應義塾大学病院および研究参加施設に入院加療し軽快退院した患者の、肺及び他の後遺症の実態を明らかにすることを目的とした。新型コロナウイルス感染症(COVID-19)の確定診断例で、慶應病院あるいは他の研究参加施設に入院加療し、軽快退院した18 歳以上の患者に対して、同意を得て、入院中、診断3ヵ月後、診断6ヵ月後、診断1年後に、アンケート調査を行った。また肺炎を合併した中等症I 以上の患者には胸部CT 検査と一部の患者には精密肺機能検査も行った。 COVID-19罹患後症状全般としては、発症1年後でも何らかの症状を有する人は3割以上であり、中でも倦怠感、息苦しさ（息切れ）、記憶障害、集中力低下、筋力低下がより残存した。胸部CT画像および肺機能に関しては現在集計中であるが、より重症度が高い場合には、呼吸困難をより認める傾向があった。今後は層別解析など、さらに詳細な検討を行う予定である。 COVID-19 has spread globally since it was reported as pneumonia of unknown cause in China in December 2019. The sixth wave of the disease is ending in Japan, but there are signs of a re-emergence, and the epidemic is likely to repeat itself in the future. In recent years, various sequelae such as general fatigue, dyspnea, headache, and olfactory and taste disorders have been reported for a long period of time after contracting COVID-19. In particular, it has been reported that after pneumonia caused by COVID-19, fibrosis of the lungs progresses even after the virus has disappeared, resulting in low pulmonary function and persistent symptoms of dyspnea, but the actual situation in Japan is unknown. The purpose of this study was to clarify the actual status of pulmonary and other sequelae in patients who were hospitalized and treated at Keio University Hospital and participating institutions, and who were discharged from the hospital after a brief illness. Patients aged 18 years or older with a confirmed diagnosis of COVID-19 who were hospitalized and treated at Keio Hospital or other participating institutions and discharged from the hospital without illness were surveyed during hospitalization, 3 months after diagnosis, 6 months after diagnosis, and 1 year after diagnosis, after obtaining consent. Patients with moderate disease (grade I) or higher with pneumonia also underwent chest computed tomography (CT) examination, and some patients underwent a full pulmonary function test. As for overall symptoms after COVID-19, more than 30% of the patients had some symptoms even one year after the onset of the disease, with fatigue, breathlessness (shortness of breath), memory impairment, poor concentration, and muscle weakness remaining more prevalent. Dyspnea tended to be more present in more severe cases, although CT chest imaging and pulmonary function are currently being compiled. Further detailed studies, including stratified analysis, will be conducted in the near future.
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ