肺多形癌のゲノム・エピゲノム解析による新規治療開発を目指した研究

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Author: 中込, 貴博ほか

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Publication date: 2022

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Note (General)：: type:text肺多形癌手術検体を顕微鏡的に正常肺組織, 上皮成分, 肉腫様成分に区分けし, 網羅的なDNAメチル化解析を行い, 肺多形癌の発癌・形態分化にDNAメチル化による遺伝子発現の変化が関与していることが示唆された. また, 肺多形癌の発癌に関与するDNAメチル化部位が有意に影響する細胞内...

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科研費研究者番号 : 40868303

科研費研究者番号 : 40544664

科研費研究者番号 : 00260315

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Material Type: 文書・図像類
Title: 肺多形癌のゲノム・エピゲノム解析による新規治療開発を目指した研究
Author/Editor: 中込, 貴博
菱田, 智之
金井, 弥栄
Author Heading: 中込, 貴博
菱田, 智之
金井, 弥栄
Publication Date: 2022
Publication Date (W3CDTF): 2022
Alternative Title: ハイタケイガンノゲノム・エピゲノムカイセキニヨルシンキチリョウカイハツオメザシタケンキュウ
Hai takei gan no genomu epigenomu kaiseki ni yoru shinki chiryō kaihatsu o mezashita kenkyū
Genomic and epigenomic analysis of lung pleomorphic carcinoma for the development of new treatments
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 肺多形癌,肉腫様癌,エピゲノム,DNAメチル化異常,腫瘍内不均一性
Target Audience: 一般
Note (General): type:text
肺多形癌手術検体を顕微鏡的に正常肺組織, 上皮成分, 肉腫様成分に区分けし, 網羅的なDNAメチル化解析を行い, 肺多形癌の発癌・形態分化にDNAメチル化による遺伝子発現の変化が関与していることが示唆された. また, 肺多形癌の発癌に関与するDNAメチル化部位が有意に影響する細胞内シグナル伝達経路を同定. また, 発癌に関与するDNAメチル化が起きている遺伝子領域のうち, 肉腫様成分の分化に関与し, リンパ節転移・リンパ管侵襲と相関関係にある5遺伝子, 再発・生存と相関関係にある３遺伝子を同定した. Surgical specimens of lung pleomorphic carcinoma were microscopically divided into normal lung tissue, epithelial-like component, and sarcoma-like component, and subjected to comprehensive DNA methylation analysis. Comparative analysis of DNA methylation rates in each region suggested that changes in gene expression due to DNA methylation are involved in carcinogenesis and morphological differentiation of lung pleomorphic carcinoma. We identified several intracellular signaling pathways significantly affected by DNA methylation sites involved in carcinogenesis, including the FGF signaling pathway, the TGF-beta family, and WNT/Beta-catenin signaling. In addition, we identified five genes (THSD1, ZFYVE21, CDT1, LYPD1, BGLAP) correlated with lymph node metastasis and lymphatic invasion, and three genes (LOC101927151, NRN1L, PLCXD3) correlated with recurrence and survival from the DNA methylation regions involved in carcinogenesis and differentiation to sarcoma-like components.
研究種目 : 若手研究研究期間 : 2020～2022 課題番号 : 20K15771 研究分野 : 医学 (ゲノム生物学関連), 肺がんゲノム・エピゲノム異常
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 40868303
科研費研究者番号 : 40544664
科研費研究者番号 : 00260315
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ