短腸症候群モデルを用いた新規移植療法の開発

Material type: 文書・図像類

Author: 杉本, 真也

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Publication date: 2022

Material Format: Digital

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Note (General)：: type:textこれまで細胞移植の対象としてきた短腸症候群モデルラットの切除腸管長や部位の変更、周術期管理の改善によって、移植組織解析効率の上昇へとつながった。小動物レベルにおける移植先組織の移植前処置の条件の改変し、その結果を大動物へと応用した。同様にex vivo、in vivoでの課題抽出に...

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科研費研究者番号 : 20626387

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Material Type: 文書・図像類
Title: 短腸症候群モデルを用いた新規移植療法の開発
Author/Editor: 杉本, 真也
Author Heading: 杉本, 真也
Publication Date: 2022
Publication Date (W3CDTF): 2022
Alternative Title: タンチョウショウコウグンモデルオモチイタシンキイショクリョウホウノカイハツ
Tanchō shōkōgun moderu o mochiita shinki ishoku ryōhō no kaihatsu
Development of a novel transplantation therapy using a short bowel syndrome model
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 短腸症候群,小腸移植,幹細胞,腸管不全,GLP-2アナログ
Target Audience: 一般
Note (General): type:text
これまで細胞移植の対象としてきた短腸症候群モデルラットの切除腸管長や部位の変更、周術期管理の改善によって、移植組織解析効率の上昇へとつながった。小動物レベルにおける移植先組織の移植前処置の条件の改変し、その結果を大動物へと応用した。同様にex vivo、in vivoでの課題抽出によって、従来は困難であった大動物レベルでの上皮剥離効率向上へとつながった。本研究によって，ヒトへの応用へ向けた研究基盤が構築された。 Modification of the length and site of the resected intestine and improvement of perioperative management of the short bowel syndrome rat model, which has been the subject of cell transplantation, led to an increase in the efficiency of transplant tissue analysis. The conditions of pre-treatment of the recipient tissue at the small animal level were modified and the results were applied to large animals. The extraction of issues ex vivo and in vivo as well as at the small animal level has led to improved epithelial removal efficiency at the large animal level, which has previously been difficult to achieve. This research has established a basic foundation for research aimed at human application.
研究種目 : 挑戦的研究 (萌芽) 研究期間 : 2021～2022 課題番号 : 21K19540 研究分野 : 消化器病学
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 20626387
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ