FGF-23に着目したsilent lupus腎炎の新規診断法の確立

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Author: 花岡, 洋成

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Publication date: 2021

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Note (General)：: 出版タイプ： VoRtype:text本研究の目的は検尿異常のない全身性エリテマトーデス(SLE)患者において血清Fibroblast Growth Factor-23(FGF-23)値と腎予後の関係を明らかにすることである。当院に通院するSLE患者109名を対象に検尿異常の有無で全患者を2群に分類...

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Material Type: その他
Title: FGF-23に着目したsilent lupus腎炎の新規診断法の確立
Author/Editor: 花岡, 洋成
Author Heading: 花岡, 洋成
Publication Date: 2021
Publication Date (W3CDTF): 2021
Alternative Title: FGF-23 ニチャクモクシタ silent lupus ジンエンノシンキシンダンホウノカクリツ
FGF-23 ni chakumokushita silent lupus jin'en no shinki shindanhō no kakuritsu
Association of FGF-23 with silent lupus nephritis
Periodical title: 科学研究費補助金研究成果報告書
Subject Heading: 全身性エリテマトーデス
Target Audience: 一般
Note (General): 出版タイプ： VoR
type:text
本研究の目的は検尿異常のない全身性エリテマトーデス(SLE)患者において血清Fibroblast Growth Factor-23(FGF-23)値と腎予後の関係を明らかにすることである。当院に通院するSLE患者109名を対象に検尿異常の有無で全患者を2群に分類し、累積腎機能悪化率・尿バイオマーカー・FGF23を測定し比較した。疾患活動性(SLEDAI)は検尿異常がある群の方が高かった(p=0.02)。また尿バイオマーカーは差はなかった。一方2群間の累積腎機能悪化率に差はなく(p=0.32)、血清FGF23値は検尿異常を有する群で高い傾向があったが統計的に差はなかった(p=0.11) Objective of this study was to evaluate the association of FGF-23 with renal outcome in systemic lupus erythematosus (SLE). We included 109 patients with SLE and divided into 2 groups according to the presence of proteinuria or active sediment. Clinical features, urine biomarkers (b2 microgloburin, a1 microgloburin, NAG, NGAL, amd L-FABP), FGF-23 and cumulative renal deterioration rate were compared. We found 60 patients with and 49 patients without proteinuria or active sediment and there was no significant difference between the 2 groups in the cumulative renal deterioration rate (p=0.32). Regarding with clinical features, patients with proteinurina or active sediment had higher disease activity (systemic lupus erythemaosus activity index) than those without (p=0.02). We could not find any difference in urine biomaker or serum FGF-23 between the 2 groups. Patients may progress renal dysfunction regardless peroteinuria or active sediment and FGF-23 may contribute to the status.
研究種目 : 基盤研究 (C) (一般) 研究期間 : 2019～2021 課題番号 : 19K08889 研究分野 : リウマチ膠原病学
Related Material: 科研費研究者番号 : 90453547
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ