なぜビフィズス菌は腸内に定着できるのか? : 腸内細菌との共生から紐解く生存戦略

Material type: 文書・図像類

Author: 西山, 啓太

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Publication date: 2021

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Note (General)：: type:text腸内細菌は芳香族アミノ酸を様々な物質に変換し，宿主の生理状態に多くの影響を及ぼすことが知られている。本研究では，BacteroidesとLactobacillusの協調的代謝から産生される芳香族アミノ酸の代謝産物AAAがBifidobacteriumの線毛の発現を誘導し腸内定着を促...

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Material Type: 文書・図像類
Title: なぜビフィズス菌は腸内に定着できるのか? : 腸内細菌との共生から紐解く生存戦略
Author/Editor: 西山, 啓太
Author Heading: 西山, 啓太
Publication Date: 2021
Publication Date (W3CDTF): 2021
Alternative Title: ナゼビフィズスキンワチョウナイニテイチャクデキルノカ? : チョウナイサイキントノキョウセイカラヒモトクセイゾンセンリャク
Naze bifizusukin wa chōnai ni teichakudekirunoka? : chōnai saikin tono kyōsei kara himotoku seizon senryaku
The bifidobacterial gut colonization strategies based on communication between complex symbiotic intestinal microbes
Periodical title: 科学研究費補助金研究成果報告書
Text Language Code: jpn
eng
Subject Heading: 腸内細菌,ビフィズス菌,共生,代謝産物,定着
Target Audience: 一般
Note (General): type:text
腸内細菌は芳香族アミノ酸を様々な物質に変換し，宿主の生理状態に多くの影響を及ぼすことが知られている。本研究では，BacteroidesとLactobacillusの協調的代謝から産生される芳香族アミノ酸の代謝産物AAAがBifidobacteriumの線毛の発現を誘導し腸内定着を促進することを見出した。本知見は，腸内細菌が産生する特定の代謝産物がBifidobacteriumの腸管定着を制御するシグナル分子として作用することを明らかにした。 The gut microbiome converts aromatic amino acids to several metabolites that potentially regulate biological processes. Here, we show that metabolite 'AAA', produced by intestinal bacteria, upregulates the gene expression of fimbriae of Bifidobacterium, thereby dynamically inducing fimbriae elongation. AAA promoted the intestinal colonization of commensal bacteria, and inhibited the growth of gram-negative pathogenic bacteria through cell membrane disruption. Furthermore, we found that AAA was produced by metabolic exchange between two bacterial species, Bacteroides and Lactobacillus. This study revealed that AAA can act as a signaling molecule that significantly modulates bacterial colonization in the intestine. These findings demonstrate the existence of AAA-mediated trans-species dialogue between microorganisms and provide new insights into understanding the formation and maintenance of human gut microbiota.
研究種目 : 若手研究研究期間 : 2020～2021 課題番号 : 20K15438 研究分野 : 応用微生物学
Access Restrictions: 限定公開
Related Material: 科研費研究者番号 : 40756029
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 慶應義塾大学 : 慶應義塾大学学術情報リポジトリ