ゾルーゲル転移を示す生体適合ポリマー材料の開発と応用 (1)

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Author: Takata, Kazuyukiほか

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Publication date: 2019

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Note (General)：: We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows tem...

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Material Type: 文書・図像類
Title: ゾルーゲル転移を示す生体適合ポリマー材料の開発と応用 (1)
Author/Editor: Takata, Kazuyuki
Takai, Hiroki
Yoshizaki, Yuta
Nagata, Takuya
Kawahara, Keisuke
Yoshida, Yasuyuki
Kuzuya, Akinori
⼤⽮, 裕⼀
Author Heading: Takata, Kazuyuki
Takai, Hiroki
Yoshizaki, Yuta
Nagata, Takuya
Kawahara, Keisuke
Yoshida, Yasuyuki
Kuzuya, Akinori
⼤⽮, 裕⼀
Publication Date: 2019
Publication Date (W3CDTF): 2019
Periodical title: 2016-2017年度関西大学研究拠点形成支援経費研究成果報告書
Text Language Code: eng
Subject Heading: 関西大学
Kansai University
injectable polymers
sustained release
sol-to-gel transition
hydrogel
peptide drug delivery
Target Audience: 一般
Note (General): We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.
P.4~P.14 Title: Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation Journal: Gels Doi:https://doi.org/10.3390/gels3040038
本研究の⼀部は 2016-2017 年度関⻄⼤学研究拠点形成⽀援経費において，研究課題「ゾル−ゲル転移を⽰す⽣体適合ポリマー材料の開発と応⽤」として研究費を受け，その成果を公表するものである。
Access Restrictions: 限定公開
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 関西大学 : 関西大学学術リポジトリ