超臨界溶体急速膨張法による微粒子形成のための基盤構築

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Author: 東, 秀憲ほか

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Publication date: 2015-06-18

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Note (General)：: 金沢大学理工学域自然システム学系本研究では，超臨界溶体急速膨張（RESS）法に着目し，難溶性薬物の微粒化手法としての適用性について検討した．溶質には，超臨界二酸化炭素中での溶質濃度条件により，異なる形態の微粒子が得られるとの報告例のあるケトプロフェンを採用した．RESS法による微粒子の生成において、...

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https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24560921/24560921seika/

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Material Type: 文書・図像類
Title: 超臨界溶体急速膨張法による微粒子形成のための基盤構築
Author/Editor: 東, 秀憲
Higashi, Hidenori
Author Heading: 東, 秀憲
Higashi, Hidenori
Publication Date: 2015-06-18
Publication Date (W3CDTF): 2015-06-18
Alternative Title: Foundamental research for microparticle formation by rapid expansion of supercritical solution method
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2015-03-31
Volume: 2012-04-01 – 2015-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 微粒子
超臨界二酸化炭素
薬用成分
粒度分布
結晶
形態変化
拡散律速モデル
表面反応律速モデル
Target Audience: 一般
Note (General): 金沢大学理工学域自然システム学系
本研究では，超臨界溶体急速膨張（RESS）法に着目し，難溶性薬物の微粒化手法としての適用性について検討した．溶質には，超臨界二酸化炭素中での溶質濃度条件により，異なる形態の微粒子が得られるとの報告例のあるケトプロフェンを採用した．RESS法による微粒子の生成において、超臨界二酸化炭素中での溶質濃度が、生成する粒子の形態に与える影響についてSEMによる粒子の形態観察と粒度分布の測定，モデル式を用いた粒子生成メカニズムの考察を行った．その結果，高濃度域では粗大な結晶状粒子が，低濃度域では球形の微小粒子の生成が確認され，表面反応律速モデルと拡散律速モデルにより，粒子形態の変化を説明できた．
The purpose of this work is clarify the influence of the concentration of solute in supercritical carbon dioxide on the forms of the generated fine particles of medicinal component via rapid expansion of supercritical solution.Submicron fine particles and crystalline coarse particles were observed at high concentration region. Only submicron fine particles were observed at lower concentration of solute. The forms of generated particles were observed and the size distribution was determined by the SEM image.The two particle formation mechanism, surface reaction control and diffusion control models, were considered to represent the formation of submicron fine particles and crystalline coarse particles. The mean particle sizes were well represented by the two models.
研究課題/領域番号:24560921, 研究期間(年度):2012-04-01 – 2015-03-31
DOI: 10.24517/00034452
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=40294889
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24560921/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24560921/24560921seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA