含硫黄多環芳香族化合物を指標とする越境大気汚染物質の人体曝露評価法の開発

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Author: 鳥羽, 陽ほか

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Publication date: 2015-05-28

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Note (General)：: 金沢大学医薬保健研究域薬学系中国において大気汚染の主要な発生源となっている石炭燃焼由来の有機汚染物質で，黄砂を含め日本へ長距離輸送されている可能性が高いと推定される石炭燃焼マーカーとして含硫黄多環芳香族化合物(PASHs)を提案し，尿中代謝物を生体指標（バイオマーカー）とする石炭燃焼煙の人体曝露評価...

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https://kaken.nii.ac.jp/search/?qm=50313680

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590160/

https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590160/24590160seika/

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Material Type: 文書・図像類
Title: 含硫黄多環芳香族化合物を指標とする越境大気汚染物質の人体曝露評価法の開発
Author/Editor: 鳥羽, 陽
Toriba, Akira
Author Heading: 鳥羽, 陽
Toriba, Akira
Publication Date: 2015-05-28
Publication Date (W3CDTF): 2015-05-28
Alternative Title: Development of a method for assessing human exposure to cross-boundary air pollutions by polycyclic aromatic sulfur heterocyclic compounds as chemical markers
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2015-03-31
Volume: 2012-04-01 – 2015-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: バイオマーカー
石炭燃焼
越境汚染
曝露評価
アジア
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域薬学系
中国において大気汚染の主要な発生源となっている石炭燃焼由来の有機汚染物質で，黄砂を含め日本へ長距離輸送されている可能性が高いと推定される石炭燃焼マーカーとして含硫黄多環芳香族化合物(PASHs)を提案し，尿中代謝物を生体指標（バイオマーカー）とする石炭燃焼煙の人体曝露評価法を開発することを目的とした。代表的なPASHsの中からヒトへの曝露量が高いと予測できたdibenzothiophene (DBT)をマーカー候補とし，DBT投与ラット尿中から代謝物を同定し，代謝経路を明らかにすることに成功した。同定された主代謝物をバイオマーカー候補とし，実際にヒト尿試料から検出できる可能性が示唆された。
Polycyclic aromatic sulfur heterocyclic compounds (PASHs) are organic pollutants from coal combustion, which has become a major source of air pollution in China and are estimated to be a cross-boundary pollutant such as Asian dust. Urinary metabolites of PASHs as a biomarker for coal burning exposure were examined in this study. Dibenzothiophene (DBT) was predicted to have high exposures to humans in the tested PASH candidates. DBT metabolites from DBT administered rat urine were successfully identified and its metabolic pathway was elucidated. The analysis of human urine samples suggested the possibility of the metabolite excretion. It is concluded that the identified major metabolite is a convincing biomarker candidate for the biomarker of exposure to coal-burning smoke.
研究課題/領域番号:24590160, 研究期間(年度):2012-04-01 – 2015-03-31
DOI: 10.24517/00034464
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=50313680
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590160/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24590160/24590160seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA