3-D浸潤性獲得と上皮形態形成制御を基盤とする腫瘍悪性化機構の研究

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Author: 松本, 邦夫ほか

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Publication date: 2015-06-08

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Note (General)：: 金沢大学がん進展制御研究所がん細胞の高い浸潤性はがん転移につながる。本研究は、がん細胞における浸潤能獲得機構をエピジェネティック制御異常ならびにHGF-Met系シグナル特性から明らかにするとともに、HGF-Met相互作用を基盤として人工Met制御分子の創製を目的とした。その結果、(1) PRC複合体...

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https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24300329/

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Material Type: 文書・図像類
Title: 3-D浸潤性獲得と上皮形態形成制御を基盤とする腫瘍悪性化機構の研究
Author/Editor: 松本, 邦夫
Matsumoto, Kunio
Author Heading: 松本, 邦夫
Matsumoto, Kunio
Publication Date: 2015-06-08
Publication Date (W3CDTF): 2015-06-08
Alternative Title: Mechanisms for malignant tumor progression based on acquisition of 3-D invesiveness and regulation of epithelial morphogenesis
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(B) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2015-03-31
Volume: 2012-04-01 – 2015-03-31
Pages: 6p.-
Text Language Code: jpn
Subject Heading: 細胞増殖因子
転移
薬剤耐性
HGF
Met
浸潤
人工アゴニスト
環状ペプチド
Target Audience: 一般
Note (General): 金沢大学がん進展制御研究所
がん細胞の高い浸潤性はがん転移につながる。本研究は、がん細胞における浸潤能獲得機構をエピジェネティック制御異常ならびにHGF-Met系シグナル特性から明らかにするとともに、HGF-Met相互作用を基盤として人工Met制御分子の創製を目的とした。その結果、(1) PRC複合体構成分子のタンパク質分解異常による機能破綻が、MMP-2を含む浸潤関連遺伝子の発現OFF→ONに関与すること、(2) Met-low→Met-highへの階層的発現変化が悪性黒色種の腫瘍成長、浸潤・転移性に関与することを明らかにするとともに、(3) 環状ペプチド性人工Met-アゴニスト/人工HGFの創製に成功した。
Tumor invasion, a typical characteristic of malignant tumors, is regulated not only by intrinsic gene expression profile but also extracellular factors. Met activation by HGF participates in tissue regeneration and tumor invasion. We here found that 1) aberrant proteasome-mediated proteolysis in PRC complex participates in activation of genes (e.g., MMP-2) involved in acquisition of 3-D invasiveness in human malignant mesothelioma cells, and 2) Met expression is regulated by hierarchal equilibrium between Met-low and Met-high populations in malignant melanoma cells, by which invasive and metastatic characteristics is conferred. Based on background for HGF-Met protein-protein interactions, Met-binding cyclic peptides were obtained by RaPID system, and the dimerized peptides induced Met activation and Met-mediated biological responses, in indistinguishable ability to HGF. Thus, we succeeded in generation of artificial Met-agonist / artificial HGF composed of macrocyclic peptide.
研究課題/領域番号:24300329, 研究期間(年度):2012-04-01 – 2015-03-31
DOI: 10.24517/00034479
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=90201780
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24300329/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24300329/24300329seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA