近赤外光による非侵襲的子宮内胎児機能診断システムの臨床評価

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Author: 野川, 雅道ほか

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Publication date: 2015-06-25

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Note (General)：: 金沢大学理工学域機械工学系Toward a development of non-invasive near-infrared assessment system for intrauterine fetal well-being, we have evaluated the performance...

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Material Type: 文書・図像類
Title: 近赤外光による非侵襲的子宮内胎児機能診断システムの臨床評価
Author/Editor: 野川, 雅道
Nogawa, Masamichi
Author Heading: 野川, 雅道
Nogawa, Masamichi
Publication Date: 2015-06-25
Publication Date (W3CDTF): 2015-06-25
Alternative Title: Development of non-invasive near-infrared assessment system for intrauterine fetal well-being
Periodical title: 平成26(2014)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2014 Fiscal Year Final Research Report
No. or year of volume/issue: 2012-04-01 – 2015-03-31
Volume: 2012-04-01 – 2015-03-31
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 胎児血中酸素飽和度
パルスオキシメータ
放射輸送方程式
光拡散方程式
Target Audience: 一般
Note (General): 金沢大学理工学域機械工学系
Toward a development of non-invasive near-infrared assessment system for intrauterine fetal well-being, we have evaluated the performance of the proposed system, which offers non-invasive transabdominal measurement of fetal arterial oxygen saturation, with pregnant women in regular prenatal care. The proposed system consists of three major parts: a two-wavelength transabdominal fetal photo-plethysmography (750/830nm), frequency domain signal extraction procedure of fetal plethysmogram from transabdominal photo-plethysmogram, and non-blood drawing sensor calibration procedure based on radiative transfer for safe and reliable non-invasive fetal arterial oxygen saturation measurement. As a result of the clinical trials, the non-invasive fetal assessment system could offer acceptable normal arterial oxygen saturation ranges of intrauterine fetuses: 50-70%. 近赤外光による非侵襲的子宮内胎児機能診断システムの臨床評価にあたり，胎児血中酸素飽和度の非侵襲測定を実現するには，従来，事前に複数の胎児を対象に低酸素負荷時に採血試験を行い，光センサ出力との関係を校正する必要があった．しかしながら，このような校正法は危険を伴うため，光散乱理論を用い，妊婦腹部を模擬した数値モデルにおいて，子宮内胎児の光電容積信号（波長：750/830nm）から血中酸素飽和度を求める校正曲線を理論的（非採血的）に導出した．実際の妊婦腹部表面から得られた光電容積信号を用いて評価した結果，それぞれの酸素飽和度は生理学的な正常値（母体：98％前後，胎児：50～70％前後）を示した．
研究課題/領域番号:24500540, 研究期間(年度):2012-04-01 – 2015-03-31
DOI: 10.24517/00034484
Source: https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=34497&item_no=1&attribute_id=26&file_no=1
https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=34497&item_no=1&attribute_id=26&file_no=1
Access Restrictions: 限定公開
Rights (production): CC BY-NC-ND
Related Material: https://kaken.nii.ac.jp/search/?qm=40292445
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24500540/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-24500540/24500540seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA