分子標的療法の導入を視野に入れた胃癌におけるHER2異常の包括的検討

Material type: 文書・図像類

Author: 大井, 章史ほか

Publisher: 金沢大学医学系

Publication date: 2013-05-10

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Note (General)：: 金沢大学医薬保健研究域医学系免疫組織化学とfluorescence in situ hybridization (FISH) を使って475例の胃癌を検索した結果、51 例にHER2遺伝子増幅を持った癌細胞を認め、21 例(42%)でその増幅は不均一であった。Multiplex ligation-d...

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Material Type: 文書・図像類
Title: 分子標的療法の導入を視野に入れた胃癌におけるHER2異常の包括的検討
Author/Editor: 大井, 章史
Ooi, Akishi
Author Heading: 大井, 章史
Ooi, Akishi
Publication, Distribution, etc.: 金沢大学医学系
Publication Date: 2013-05-10
Publication Date (W3CDTF): 2013-05-10
Alternative Title: A comprehensive study of HER2 aberration of gastric cancers in viewing as the target of molecular therapy
Periodical title: 平成24(2012)年度科学研究費補助金基盤研究(C) 研究成果報告書 = 2012 Fiscal Year Final Research Report
No. or year of volume/issue: 2010-2012
Volume: 2010-2012
Pages: 4p.-
Text Language Code: jpn
Subject Heading: 胃癌
HER2
分子標的療法
遺伝子増幅
FISH
Target Audience: 一般
Note (General): 金沢大学医薬保健研究域医学系
免疫組織化学とfluorescence in situ hybridization (FISH) を使って475例の胃癌を検索した結果、51 例にHER2遺伝子増幅を持った癌細胞を認め、21 例(42%)でその増幅は不均一であった。Multiplex ligation-dependent probe amplification (MLPA)及びFISH では、HER2とMYCの同一腫瘍細胞内での増幅が8例に、同じくMYCとFGFR2またはEGFRの同時増幅がそれぞれ1 例にみられた。一方、HER2とEGFR 、HER2/FGFR2 , HER2/MET/FGFR2の同一腫瘍内で異なる細胞上での増幅がそれぞれ7例、1例、1例にみられた。この結果は、胃癌に対する、個別化分子標的療法を行う上で重要であると結論された。
By combined analysis of immunohistochemistry and fluorescence in situ hybridization (FISH) on 475 formalin-fixed paraffin-embedded tissue, 51 gastric adenocarcinoma with HER2-amplified cancer cells. The heterogeneity of HER2 amplification, if defined as the existence of less than 50% of cancer cells positive for ERBB2 amplification, the 21 tumors (42%) would be heterogeneous. The combined analysis of multiplex ligation-dependent probe amplification (MLPA) and FISH revealed that, co-amplification in individual cells of HER2 and MYC were found in 8 tumors and MYC/FGFR2, and MYC/EGFR in a case respectively. On the other hand, co-amplification of HER2/EGFR in 7, HER2/FGFR2 in one tumor and HER2/MET/FGFR2 in a tumor, however the respective genes were mutually exclusively amplified. In conclusion, the semi-comprehensive information of amplification status of HER2 and other genes obtained by the combined study of MLPA and FISH may be useful to plan individualized molecular target therapy against gastric cancers.
研究課題/領域番号:22590310, 研究期間(年度):2010–2012
出典：研究課題「分子標的療法の導入を視野に入れた胃癌におけるHER2異常の包括的検討」研究課題番号22590310（KAKEN：科学研究費助成事業データベース（国立情報学研究所））（https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590310/22590310seika/）を加工して作成
DOI: 10.24517/00034561
Access Restrictions: 限定公開
Related Material: https://kaken.nii.ac.jp/search/?qm=50160411
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590310/
https://kaken.nii.ac.jp/report/KAKENHI-PROJECT-22590310/22590310seika/
Data Provider (Database): 国立情報学研究所 : 学術機関リポジトリデータベース（IRDB）（機関リポジトリ）
https://irdb.nii.ac.jp
Original Data Provider (Database): 金沢大学 : 金沢大学学術情報リポジトリKURA